PMID- 28099727
OWN - NLM
STAT- MEDLINE
DCOM- 20170516
LR  - 20170516
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 136
IP  - 2
DP  - 2017 Feb
TI  - Association of biochemical markers with the severity of pre-eclampsia.
PG  - 138-144
LID - 10.1002/ijgo.12029 [doi]
AB  - OBJECTIVE: To assess the association between pre-eclampsia severity and
      biochemical and ultrasonography markers. METHODS: A retrospective study was
      undertaken of women with severe pre-eclampsia (group 1, n=90), mild pre-eclampsia
      (group 2, n=90), or a normal pregnancy (group 3, n=90) who attended a hospital in
      Egypt in October 2013-April 2015. Associations between pre-eclampsia and
      biochemical, cardiotocography, and ultrasonography markers were investigated.
      RESULTS: There were significant differences between the groups in C-reactive
      protein (331.44+/-112.38, 251.43+/-59.05, and 23.81+/-16.19 nmol/L; P</=0.05 for 
      all), platelet count (113.40+/-36.72, 172.93+/-57.60, and 212.68+/-70.00x10(9)
      /L; P</=0.05 for group 1 comparisons), alanine transaminase (52.24+/-14.83,
      38.34+/-13.12, and 23.11+/-6.92 U/L; P</=0.05 for group 1 comparisons), and serum
      uric acid (600.80+/-117.19, 481.83+/-118.97, and 243.89+/-53.54 mumol/L; P=0.050 
      for group 3 comparisons). Cardiotocography score was worse among women with
      severe pre-eclampsia than among those in the other two groups (P=0.039 for both
      comparisons). Biophysical profile score and umbilical artery resistance index
      differed by group (P</=0.05 for all). Middle cerebral artery resistance index was
      lower among women with severe pre-eclampsia (P</=0.05). CONCLUSION: The levels of
      C-reactive protein, blood urea nitrogen, serum uric acid, and alanine
      transaminase, and the platelet count were linked with the presence and severity
      of pre-eclampsia.
CI  - (c) 2016 International Federation of Gynecology and Obstetrics.
FAU - Maged, Ahmed M
AU  - Maged AM
AD  - Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, 
      Cairo, Egypt.
FAU - Aid, Gamal
AU  - Aid G
AD  - Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, 
      Cairo, Egypt.
FAU - Bassiouny, Nehal
AU  - Bassiouny N
AD  - Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, 
      Cairo, Egypt.
FAU - Eldin, Doaa S
AU  - Eldin DS
AD  - Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, 
      Cairo, Egypt.
FAU - Dahab, Sherif
AU  - Dahab S
AD  - Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, 
      Cairo, Egypt.
FAU - Ghamry, Nevein K
AU  - Ghamry NK
AD  - Department of Obstetrics and Gynecology, Kasr AlAiny Hospital, Cairo University, 
      Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20161116
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (Biomarkers)
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Biomarkers/*blood
MH  - Blood Urea Nitrogen
MH  - C-Reactive Protein/analysis
MH  - Egypt
MH  - Female
MH  - Humans
MH  - Platelet Count
MH  - Pre-Eclampsia/blood/*diagnosis
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Ultrasonography
MH  - Uric Acid/blood
MH  - Young Adult
OTO - NOTNLM
OT  - *Biochemical markers
OT  - *C-reactive protein
OT  - *Maternal complications
OT  - *Neonatal complications
OT  - *Severe pre-eclampsia
EDAT- 2017/01/19 06:00
MHDA- 2017/05/17 06:00
CRDT- 2017/01/19 06:00
PHST- 2016/06/07 00:00 [received]
PHST- 2016/08/17 00:00 [revised]
PHST- 2016/10/27 00:00 [accepted]
PHST- 2017/01/19 06:00 [entrez]
PHST- 2017/01/19 06:00 [pubmed]
PHST- 2017/05/17 06:00 [medline]
AID - 10.1002/ijgo.12029 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2017 Feb;136(2):138-144. doi: 10.1002/ijgo.12029. Epub
      2016 Nov 16.