PMID- 28091892
OWN - NLM
STAT- MEDLINE
DCOM- 20180115
LR  - 20181202
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 27
IP  - 7
DP  - 2017 Jul
TI  - Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in
      Increased Bone Remodeling in Humans.
PG  - 1789-1796
LID - 10.1007/s11695-017-2546-4 [doi]
AB  - PURPOSE: Bariatric surgery has been associated with bone remodeling changes. The 
      action of adipokines on the expression of receptor activator of nuclear factor
      kappa beta ligand (RANKL) and osteoprotegerin (OPG) and on an increase in
      sclerostin could be related to these changes. MATERIALS AND METHODS: This study
      aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free
      mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers
      after Roux-en-Y gastric bypass (RYGB). Anthropometric data, parathyroid hormone
      (PTH), bone-specific alkaline phosphatase (BSAP), collagen type 1 C-telopeptide
      (CTX), 25-hydroxy vitamin D (25-OH-VitD), leptin, adiponectin, RANKL, OPG, and
      sclerostin of 30 menstruating women were measured preoperatively (Pre), and 3,
      12, and 24 months (m) after RYGB. RESULTS: Leptin (34.4 (14.7; 51.9) vs. 22.5
      (1.9; 52.7) ng/mL) and OPG (3.6 (1.1; 11.5) vs. 3.4 (1.5; 6) pmol/L) decreased,
      and adiponectin (7.4 (1.7; 18.4) vs. 13.8 (3.0; 34.6) mug/mL), CTX (0.2 (0.1;
      2.2) vs. 0.6 (0.4; 6.0) ng/mL), RANKL (0.1 (0.0; 0.5) vs. 0.3 (0.0; 2.0) pmol/L),
      and sclerostin (21.7 (3.2; 75.1) vs. 34.8 (6.4; 80.5) pmol/L) increased after 3
      m. BSAP increased after 12 m (10.1 (5.4; 18.9) vs. 13.9 (6.9; 30.2) mug/mL) (p < 
      0.005). CTX correlated positively with adiponectin at 24 m and inversely with
      leptin Pre; OPG at 3 m; weight, FM, FFM, and leptin at 24 m. RANKL correlated
      directly with weight at 3 m. Sclerostin correlated inversely with weight Pre and 
      FM at 3 m. BSAP correlated negatively with 25-OH-VitD at 12 m, and positively
      with PTH at 24 m. CONCLUSIONS: RYGB induced weight loss, and biochemical,
      hormonal, and body composition changes are associated with higher bone
      remodeling.
FAU - Biagioni, Maria Fernanda G
AU  - Biagioni MFG
AD  - Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical
      School, Sao Paulo State University, FMB-Unesp, Botucatu, Brazil.
      mafebiagioni@yahoo.com.br.
AD  - Internal Medicine Department, Botucatu Medical School, Sao Paulo State
      University, FMB-Unesp, Rubiao Junior District, no number, Botucatu, SP,
      18618-970, Brazil. mafebiagioni@yahoo.com.br.
FAU - Mendes, Adriana L
AU  - Mendes AL
AD  - Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical
      School, Sao Paulo State University, FMB-Unesp, Botucatu, Brazil.
FAU - Nogueira, Celia Regina
AU  - Nogueira CR
AD  - Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical
      School, Sao Paulo State University, FMB-Unesp, Botucatu, Brazil.
FAU - Leite, Celso V
AU  - Leite CV
AD  - Surgery Department (CVL), Botucatu Medical School, Sao Paulo State University,
      FMB-Unesp, Botucatu, Brazil.
FAU - Gollino, Loraine
AU  - Gollino L
AD  - Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical
      School, Sao Paulo State University, FMB-Unesp, Botucatu, Brazil.
FAU - Mazeto, Glaucia Mfs
AU  - Mazeto GM
AD  - Internal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical
      School, Sao Paulo State University, FMB-Unesp, Botucatu, Brazil.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Genetic Markers)
RN  - 0 (Osteoprotegerin)
RN  - 0 (RANK Ligand)
RN  - 0 (SOST protein, human)
RN  - 0 (TNFRSF11B protein, human)
SB  - IM
MH  - Adipocytes/*metabolism
MH  - Adipokines/blood/*metabolism
MH  - Adult
MH  - Anthropometry
MH  - Biomarkers/blood/metabolism
MH  - Bone Morphogenetic Proteins/*biosynthesis/blood
MH  - Bone Remodeling/*physiology
MH  - Female
MH  - *Gastric Bypass
MH  - Genetic Markers
MH  - Humans
MH  - Middle Aged
MH  - Obesity/blood/metabolism/*surgery
MH  - Osteoprotegerin/*biosynthesis/blood
MH  - Prospective Studies
MH  - RANK Ligand/*biosynthesis/blood
MH  - Weight Loss/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - *Bariatric surgery
OT  - *Biomarkers
OT  - *Bone remodeling
OT  - *Cytokines
OT  - *Wnt/beta-catenin/LRPs
EDAT- 2017/01/17 06:00
MHDA- 2018/01/16 06:00
CRDT- 2017/01/17 06:00
PHST- 2017/01/17 06:00 [pubmed]
PHST- 2018/01/16 06:00 [medline]
PHST- 2017/01/17 06:00 [entrez]
AID - 10.1007/s11695-017-2546-4 [doi]
AID - 10.1007/s11695-017-2546-4 [pii]
PST - ppublish
SO  - Obes Surg. 2017 Jul;27(7):1789-1796. doi: 10.1007/s11695-017-2546-4.