PMID- 28079773
OWN - NLM
STAT- MEDLINE
DCOM- 20170713
LR  - 20180610
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 129
IP  - 2
DP  - 2017 Feb
TI  - Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of
      Cardiometabolic Disorders.
PG  - 273-280
LID - 10.1097/AOG.0000000000001863 [doi]
AB  - OBJECTIVE: To assess the association of subsequent pregnancy with subsequent
      metabolic syndrome and type II diabetes mellitus after a pregnancy complicated by
      mild gestational diabetes mellitus (GDM). METHODS: We conducted a prospective
      observational follow-up study of women with mild GDM randomized from 2002 to 2007
      to usual care or dietary intervention and glucose self-monitoring. Women were
      evaluated 5-10 years after the parent study. Participants were grouped according 
      to the number of subsequent pregnancies (group A, none [reference]; group B, one;
      group C, two or greater). Serum triglycerides, glucose tolerance, high-density
      lipoprotein cholesterol, blood pressure, and waist circumference were assessed.
      Metabolic syndrome was diagnosed by American Heart Association and National Heart
      Lung and Blood Institute criteria. Multivariable regression was used to estimate 
      adjusted relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: Of 905
      eligible women from the original trial, 483 agreed to participate, 426 of whom
      were included in this analysis. Groups A, B, and C consisted of 212, 143, and 71 
      women, respectively. Of women with subsequent pregnancies, 32% (69/214) had
      another pregnancy complicated with GDM. No difference between groups was observed
      for metabolic syndrome (group A, 34%; group B, 33%; group C, 30%). Subsequent
      pregnancies were associated with diabetes mellitus outside of pregnancy (group A,
      5.2%; group B, 10.5%, RR 2.62, 95% CI 1.16-5.91; group C, 11.3%, RR 2.83, 95% CI 
      1.06-7.59), and if complicated with GDM (no subsequent GDM pregnancy, RR 1.99,
      95% CI 0.82-4.84; subsequent GDM pregnancy, RR 3.75, 95% CI 1.60-8.82).
      CONCLUSION: In women with prior mild GDM, subsequent pregnancies did not increase
      the frequency of metabolic syndrome, but subsequent pregnancies with GDM
      increased the risk of diabetes mellitus outside of pregnancy.
FAU - Varner, Michael W
AU  - Varner MW
AD  - Departments of Obstetrics and Gynecology, University of Utah Health Sciences
      Center, Salt Lake City, Utah, The Ohio State University, Columbus, Ohio,
      University of Texas Southwestern Medical Center, Dallas, Texas, Columbia
      University, New York, New York, Brown University, Providence, Rhode Island,
      University of Alabama at Birmingham, Birmingham, Alabama, University of North
      Carolina, Chapel Hill, North Carolina; MetroHealth Medical Center-Case Western
      Reserve University, Cleveland, Ohio, University of Texas Medical Branch,
      Galveston, Texas, Northwestern University, Chicago, Illinois, University of Texas
      Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston,
      Texas, and Medical University of South Carolina, Charleston, South Carolina; the 
      George Washington University Biostatistics Center, Washington, DC; and the Eunice
      Kennedy Shriver National Institute of Child Health and Human Development.
FAU - Rice, Madeline Murguia
AU  - Rice MM
FAU - Landon, Mark B
AU  - Landon MB
FAU - Casey, Brian M
AU  - Casey BM
FAU - Reddy, Uma M
AU  - Reddy UM
FAU - Wapner, Ronald J
AU  - Wapner RJ
FAU - Rouse, Dwight J
AU  - Rouse DJ
FAU - Tita, Alan T N
AU  - Tita AT
FAU - Thorp, John M
AU  - Thorp JM
FAU - Chien, Edward K
AU  - Chien EK
FAU - Saade, George R
AU  - Saade GR
FAU - Peaceman, Alan M
AU  - Peaceman AM
FAU - Blackwell, Sean C
AU  - Blackwell SC
FAU - Vandorsten, J Peter
AU  - Vandorsten JP
CN  - Eunice Kennedy Shriver National Institute of Child Health and Human Development
      (NICHD) Maternal-Fetal Medicine Units (MFMU) Network
LA  - eng
GR  - UL1 TR001070/TR/NCATS NIH HHS/United States
GR  - U10 HD040500/HD/NICHD NIH HHS/United States
GR  - UG1 HD027869/HD/NICHD NIH HHS/United States
GR  - U10 HD040544/HD/NICHD NIH HHS/United States
GR  - UG1 HD034116/HD/NICHD NIH HHS/United States
GR  - UG1 HD040560/HD/NICHD NIH HHS/United States
GR  - UG1 HD087230/HD/NICHD NIH HHS/United States
GR  - UG1 HD053097/HD/NICHD NIH HHS/United States
GR  - UG1 HD027915/HD/NICHD NIH HHS/United States
GR  - U10 HD040485/HD/NICHD NIH HHS/United States
GR  - UG1 HD040544/HD/NICHD NIH HHS/United States
GR  - UG1 HD034208/HD/NICHD NIH HHS/United States
GR  - UG1 HD040512/HD/NICHD NIH HHS/United States
GR  - U10 HD034116/HD/NICHD NIH HHS/United States
GR  - U10 HD027869/HD/NICHD NIH HHS/United States
GR  - U10 HD027915/HD/NICHD NIH HHS/United States
GR  - UG1 HD040545/HD/NICHD NIH HHS/United States
GR  - UL1 TR000439/TR/NCATS NIH HHS/United States
GR  - UG1 HD040485/HD/NICHD NIH HHS/United States
GR  - U10 HD040560/HD/NICHD NIH HHS/United States
GR  - U10 HD034208/HD/NICHD NIH HHS/United States
GR  - U10 HD053097/HD/NICHD NIH HHS/United States
GR  - UG1 HD040500/HD/NICHD NIH HHS/United States
GR  - U10 HD040512/HD/NICHD NIH HHS/United States
GR  - P2C HD050924/HD/NICHD NIH HHS/United States
GR  - U10 HD036801/HD/NICHD NIH HHS/United States
GR  - U10 HD040545/HD/NICHD NIH HHS/United States
GR  - U01 HD036801/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Cardiovascular Diseases/*etiology
MH  - Cholesterol, HDL/blood
MH  - Diabetes Mellitus, Type 2/*etiology
MH  - Diabetes, Gestational/*blood/etiology/therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Metabolic Syndrome/*etiology
MH  - Parity
MH  - Postpartum Period/*blood
MH  - Pregnancy
MH  - Prospective Studies
MH  - Risk Factors
MH  - Triglycerides/blood
MH  - Waist Circumference
PMC - PMC5352568
MID - NIHMS835362
EDAT- 2017/01/13 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/01/13 06:00
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2017/01/13 06:00 [entrez]
AID - 10.1097/AOG.0000000000001863 [doi]
PST - ppublish
SO  - Obstet Gynecol. 2017 Feb;129(2):273-280. doi: 10.1097/AOG.0000000000001863.