PMID- 28049561
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20170424
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 213
IP  - 4
DP  - 2017 Apr
TI  - Achieving clear margins. Directed shaving using MarginProbe, as compared to a
      full cavity shave approach.
PG  - 627-630
LID - S0002-9610(16)31150-3 [pii]
LID - 10.1016/j.amjsurg.2016.12.019 [doi]
AB  - BACKGROUND: Following lumpectomy, full cavity shaving approach is used to reduce 
      positive margin rates, among other issues previously studied by others, at an
      expense of increase in tissue volume removed. We present our experience after
      switching from full cavity shaving to a targeted shaving approach using
      MarginProbe, an intra-operative margin assessment device. METHODS: Specimen
      excision was performed according to standard of care. Additional shavings were
      taken based on device readings on the lumpectomy specimen. Intra-operative
      imaging was used, as required. RESULTS: We compared 137 MarginProbe cases to 199 
      full cavity shave cases. The re-excision rate was reduced by 57% (P = 0.026),
      from 15.1% to 6.6%. The overall tissue volume removed was reduced by 32% (P =
      0.0023), from 115 cc to 78 cc. CONCLUSIONS: MarginProbe enabled a change in the
      lumpectomy technique from full cavity shavings to directed shavings guided by the
      device. There was a significant reduction in re-excisions and in the overall
      tissue volume removed.The lower amount of shavings also contributed to a
      reduction in pathology work.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Coble, Jeffrey
AU  - Coble J
AD  - University of Iowa Hospital and Clinics, 200 Hawkins Dr., Iowa City, IA 52242,
      USA.
FAU - Reid, Vincent
AU  - Reid V
AD  - University of Iowa Hospital and Clinics, 200 Hawkins Dr., Iowa City, IA 52242,
      USA; Hall-Perrine Cancer Center: Mercy Hospital, 701 10th St, Cedar Rapids, IA
      52403, USA. Electronic address: vreid@mercycare.org.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20161230
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - AIM
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/*pathology/*surgery
MH  - Female
MH  - Humans
MH  - Intraoperative Care/*instrumentation
MH  - *Margins of Excision
MH  - Mastectomy, Segmental/*instrumentation
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/prevention & control
MH  - Neoplasm, Residual/prevention & control
MH  - Retrospective Studies
MH  - Spectrum Analysis/instrumentation
EDAT- 2017/01/05 06:00
MHDA- 2017/04/25 06:00
CRDT- 2017/01/05 06:00
PHST- 2016/06/30 00:00 [received]
PHST- 2016/12/18 00:00 [revised]
PHST- 2016/12/29 00:00 [accepted]
PHST- 2017/01/05 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
PHST- 2017/01/05 06:00 [entrez]
AID - S0002-9610(16)31150-3 [pii]
AID - 10.1016/j.amjsurg.2016.12.019 [doi]
PST - ppublish
SO  - Am J Surg. 2017 Apr;213(4):627-630. doi: 10.1016/j.amjsurg.2016.12.019. Epub 2016
      Dec 30.