PMID- 27998550
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20171012
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 214
IP  - 4
DP  - 2017 Oct
TI  - The clinical implication of the number of lymph nodes harvested during sentinel
      lymph node biopsy and its effects on survival outcome in patients with
      node-negative breast cancer.
PG  - 726-732
LID - S0002-9610(16)30954-0 [pii]
LID - 10.1016/j.amjsurg.2016.10.019 [doi]
AB  - BACKGROUND: The optimal number of sentinel lymph nodes (SLN) that need to be
      harvested to achieve favorable survival outcome during a SLN biopsy (SLNB) has
      not yet been established. METHODS: Six hundred and thirteen patients with
      clinically node-negative breast cancer who underwent SLNB were reviewed. Survival
      outcomes according to the number of total harvested lymph nodes (THLNs), defined 
      as the sum of enumerated SLNs and non-SLNs were analyzed. RESULTS: Patients with 
      only 1 THLN showed lower recurrence-free survival (RFS) as compared to those with
      >/=2 THLNs (p = 0.049). In multivariate analysis, only 1 THLN was associated with
      poor RFS (HR = 2.711; p = 0.029). CONCLUSIONS: Removing at least 2 lymph nodes
      during SLNB may be acceptable. Harvesting only 1 lymph node should be undertaken 
      cautiously because of false negative results and increasing the subsequent
      recurrence rate.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Kim, Mi Kyoung
AU  - Kim MK
AD  - Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
FAU - Park, Hyung Seok
AU  - Park HS
AD  - Department of Surgery, Yonsei University College of Medicine, Republic of Korea. 
      Electronic address: imgenius@yuhs.ac.
FAU - Kim, Jee Ye
AU  - Kim JY
AD  - Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
FAU - Kim, Sanghwa
AU  - Kim S
AD  - Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
FAU - Nam, Sanggeun
AU  - Nam S
AD  - Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
FAU - Park, Seho
AU  - Park S
AD  - Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
FAU - Kim, Seung Il
AU  - Kim SI
AD  - Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20161130
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - AIM
SB  - IM
CIN - Am J Surg. 2017 Jul;214(1):162. PMID: 28069107
MH  - Axilla
MH  - Breast Neoplasms/*pathology/therapy
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - *Lymph Node Excision
MH  - Lymphatic Metastasis/*pathology
MH  - Middle Aged
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Sentinel Lymph Node Biopsy/*methods
MH  - Survival Rate
OTO - NOTNLM
OT  - Breast
OT  - Neoplasms
OT  - Optimal number
OT  - Prognosis
OT  - Sentinel lymph node biopsy
OT  - Survival
EDAT- 2016/12/22 06:00
MHDA- 2017/09/28 06:00
CRDT- 2016/12/22 06:00
PHST- 2016/07/15 00:00 [received]
PHST- 2016/09/26 00:00 [revised]
PHST- 2016/10/24 00:00 [accepted]
PHST- 2016/12/22 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2016/12/22 06:00 [entrez]
AID - S0002-9610(16)30954-0 [pii]
AID - 10.1016/j.amjsurg.2016.10.019 [doi]
PST - ppublish
SO  - Am J Surg. 2017 Oct;214(4):726-732. doi: 10.1016/j.amjsurg.2016.10.019. Epub 2016
      Nov 30.