PMID- 27907108
OWN - NLM
STAT- MEDLINE
DCOM- 20170703
LR  - 20170703
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 12
DP  - 2016
TI  - Mupirocin in the Treatment of Staphylococcal Infections in Chronic
      Rhinosinusitis: A Meta-Analysis.
PG  - e0167369
LID - 10.1371/journal.pone.0167369 [doi]
AB  - BACKGROUND: Saline irrigation of the nasal cavity is a classic and effective
      treatment for acute or chronic rhinosinusitis. Topical antibiotics such as
      mupirocin have been widely used for recalcitrant chronic rhinosinusitis.
      Therefore, the purpose of this study was to evaluate the effect of saline
      irrigation using mupirocin. METHODS: A systematic literature review and
      meta-analysis of mupirocin saline irrigation were performed using EMBASE,
      MEDLINE, and Cochrane library through December 2015. Data were analyzed with R
      3.2.2 software. A random effects model was used because of the diversity of
      included studies. Sensitivity analysis of particular tested groups and single
      proportion tests were also performed. The main outcome measure was residual
      staphylococcal infection, as confirmed by culture or PCR. RESULTS: Two RCTs, two 
      prospective studies and two retrospective studies were included. A random effects
      model meta-analysis of the pooled data identified a relative risk of residual
      infection of 0.13 (95% CI: 0.06-0.26, p<0.05) with low heterogeneity (I2 = 0%).
      The proportion of residual staphylococcal infections after 1 month was 0.08 (95% 
      CI: 0.04-0.16). However, this proportion increased to 0.53 at 6 months (95% CI:
      0.27-0.78). CONCLUSIONS: The short-term use of mupirocin has a strongly reductive
      effect on staphylococcal infection in chronic rhinosinusitis. Although there is
      currently a lack of clear evidence, future studies with well-designed inclusion
      criteria and randomized controlled trials are needed to examine mupirocin's
      long-term effect on chronic rhinosinusitis.
FAU - Kim, Jong Seung
AU  - Kim JS
AUID- ORCID: http://orcid.org/0000-0002-1384-6799
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk 
      National University, Jeonju, Republic of Korea.
AD  - Research Institute of Clinical Medicine of Chonbuk National University-Biomedical
      Research Institute of Chonbuk National University Hospital, Jeonju, Republic of
      Korea.
FAU - Kwon, Sam Hyun
AU  - Kwon SH
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk 
      National University, Jeonju, Republic of Korea.
AD  - Research Institute of Clinical Medicine of Chonbuk National University-Biomedical
      Research Institute of Chonbuk National University Hospital, Jeonju, Republic of
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20161201
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - D0GX863OA5 (Mupirocin)
SB  - IM
MH  - Administration, Intranasal
MH  - Humans
MH  - Mupirocin/*therapeutic use
MH  - Nasal Cavity/drug effects/microbiology
MH  - Nasal Lavage
MH  - Paranasal Sinuses/drug effects/microbiology
MH  - Randomized Controlled Trials as Topic
MH  - Retrospective Studies
MH  - Rhinitis/*drug therapy/microbiology
MH  - Sinusitis/*drug therapy/microbiology
MH  - Staphylococcal Infections/*drug therapy
MH  - Staphylococcus aureus/drug effects/pathogenicity
MH  - Therapeutic Irrigation
PMC - PMC5132234
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/12/03 06:00
MHDA- 2017/07/04 06:00
CRDT- 2016/12/02 06:00
PHST- 2016/08/09 00:00 [received]
PHST- 2016/11/12 00:00 [accepted]
PHST- 2016/12/02 06:00 [entrez]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/07/04 06:00 [medline]
AID - 10.1371/journal.pone.0167369 [doi]
AID - PONE-D-16-31783 [pii]
PST - epublish
SO  - PLoS One. 2016 Dec 1;11(12):e0167369. doi: 10.1371/journal.pone.0167369.
      eCollection 2016.