PMID- 27875349
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20181202
IS  - 1473-6586 (Electronic)
IS  - 0963-0643 (Linking)
VI  - 27
IP  - 2
DP  - 2017 Mar
TI  - The revival of old antibiotics for treatment of uncomplicated urinary tract
      infections in the era of antibiotic stewardship.
PG  - 127-132
LID - 10.1097/MOU.0000000000000365 [doi]
AB  - PURPOSE OF REVIEW: In the era of increasing antibiotic resistance worldwide, this
      review highlights the advantages of revival of old antibiotics for treatment of
      uncomplicated urinary tract infections (uUTIs). RECENT FINDINGS: Recent studies
      have shown that these four oral old antibiotics, fosfomycin trometamol,
      nitrofurantoin, nitroxoline and pivmecillinam, show no increasing antibiotic
      resistance against uropathogens causing uUTI, are still effective for the
      treatment of uUTI and exhibit only minimal or no collateral damage as compared
      with fluoroquinolones or third-generation cephalosporines. SUMMARY: According to 
      the principles of antibiotic stewardship, the prudent use of antibiotics is
      needed. Therefore, recent international and national guidelines already favour
      these old oral antibiotics as first-choice treatment of uUTI. Unfortunately,
      implementation of these guidelines is still suboptimal.
FAU - Kranz, Jennifer
AU  - Kranz J
AD  - aDepartment for Urology and Pediatric Urology, Hospital St. Antonius, Eschweiler 
      bDepartment of Clinical Infectiology, University Hospital Carl Gustav Carus,
      Dresden cDepartment of Internal Medicine, Klinik fur Akutgeriatrie und
      Fruhrehabilitation, Ev. Krankenhaus Koln-Kalk, Cologne dUroEvidence@Deutsche
      Gesellschaft fur Urologie, Berlin eTechnical University, Munich, Germany.
FAU - Helbig, Sina
AU  - Helbig S
FAU - Mandraka, Falitsa
AU  - Mandraka F
FAU - Schmidt, Stefanie
AU  - Schmidt S
FAU - Naber, Kurt G
AU  - Naber KG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Urol
JT  - Current opinion in urology
JID - 9200621
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fluoroquinolones)
SB  - IM
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - *Antimicrobial Stewardship
MH  - Fluoroquinolones
MH  - Humans
MH  - Urinary Tract Infections/*drug therapy
EDAT- 2016/11/23 06:00
MHDA- 2018/04/04 06:00
CRDT- 2016/11/23 06:00
PHST- 2016/11/23 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2016/11/23 06:00 [entrez]
AID - 10.1097/MOU.0000000000000365 [doi]
PST - ppublish
SO  - Curr Opin Urol. 2017 Mar;27(2):127-132. doi: 10.1097/MOU.0000000000000365.