PMID- 27846139
OWN - NLM
STAT- MEDLINE
DCOM- 20180306
LR  - 20180405
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Linking)
VI  - 46
IP  - 2
DP  - 2017 Feb
TI  - The Accessory Spleen Is an Important Pitfall of 68Ga-DOTANOC PET/CT in the Workup
      for Pancreatic Neuroendocrine Neoplasm.
PG  - 157-163
LID - 10.1097/MPA.0000000000000728 [doi]
AB  - OBJECTIVE: The aim of the study was to assess the value and potential pitfalls of
      Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients 
      with suspected pancreatic neuroendocrine neoplasms (pNEN). METHODS: Consecutive
      patients referred for Ga-DOTANOC PET/CT for suspected pNEN between May 1, 2011,
      and October 31, 2014, were retrospectively assessed. Scan data were compared with
      cytological/histological final diagnosis. Pancreatic neuroendocrine neoplasm
      detection rate was determined on per-patient and per-lesion basis. Maximum
      standardized uptake values of lesions were determined. RESULTS: Fifty-eight
      patients with 65 lesions were enrolled. Twelve patients had nonconfirmed
      diagnosis; of these, 7 were positive and 5 negative at PET/CT. Of 46 patients
      with confirmed diagnosis, 36 had pNEN; of these, 33 were positive, 1 negative,
      and 2 nonevaluable at PET/CT. Ten patients had non-NE lesions, of which 8 were
      positive, 1 negative, and 1 nonevaluable at PET/CT. Of 48 patients with positive 
      PET/CT, 8 proved to have non-NE lesions, of which 6 were intrapancreatic
      accessory spleen. No significant maximum standardized uptake values difference
      was found between pNEN and non-NE lesions. CONCLUSIONS: Intrapancreatic accessory
      spleen is an important pitfall in Ga-DOTANOC PET/CT for suspected pNEN.
      Cytological/histological confirmation is mandatory before any surgical procedure 
      is undertaken.
FAU - Rufini, Vittoria
AU  - Rufini V
AD  - From the *Institute of Nuclear Medicine, daggerRoma ENETS Center of Excellence
      for the Diagnosis and Cure of Neuroendocrine Tumors, double daggerInstitute of
      Pathology, and section signDivision of Medical Physics, Universita Cattolica del 
      Sacro Cuore-Fondazione Policlinico A. Gemelli, Rome, Italy.
FAU - Inzani, Frediano
AU  - Inzani F
FAU - Stefanelli, Antonella
AU  - Stefanelli A
FAU - Castaldi, Paola
AU  - Castaldi P
FAU - Perotti, Germano
AU  - Perotti G
FAU - Cinquino, Annarita
AU  - Cinquino A
FAU - Indovina, Luca
AU  - Indovina L
FAU - Rindi, Guido
AU  - Rindi G
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
RN  - 0 (68Ga-DOTANOC)
RN  - 0 (Organometallic Compounds)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Choristoma/diagnosis/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/diagnosis/*diagnostic imaging
MH  - Organometallic Compounds
MH  - Pancreatic Neoplasms/diagnosis/*diagnostic imaging
MH  - Positron Emission Tomography Computed Tomography/*methods
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Spleen
MH  - Young Adult
EDAT- 2016/11/16 06:00
MHDA- 2018/03/07 06:00
CRDT- 2016/11/16 06:00
PHST- 2016/11/16 06:00 [pubmed]
PHST- 2018/03/07 06:00 [medline]
PHST- 2016/11/16 06:00 [entrez]
AID - 10.1097/MPA.0000000000000728 [doi]
PST - ppublish
SO  - Pancreas. 2017 Feb;46(2):157-163. doi: 10.1097/MPA.0000000000000728.