PMID- 27846138
OWN - NLM
STAT- MEDLINE
DCOM- 20180306
LR  - 20180405
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Linking)
VI  - 46
IP  - 2
DP  - 2017 Feb
TI  - Alcohol Consumption and Cigarette Smoking are Important Modifiers of the
      Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men.
PG  - 230-236
LID - 10.1097/MPA.0000000000000729 [doi]
AB  - OBJECTIVES: The present study was designed to investigate whether the
      susceptibility to acute pancreatitis (AP) attributable to polymorphism rs10273639
      at the PRSS1-PRSS2 locus is dependent on alcohol consumption and cigarette
      smoking. METHODS: A total of 603 unrelated Russian individuals including 304
      patients with physician-diagnosed AP and 299 sex- and age-matched healthy
      controls have been recruited for the study. A polymorphism rs10273639 (-408C>T)
      of PRSS1-PRSS2 was genotyped by TaqMan-based assay. RESULTS: A variant allele
      -408T (P = 0.003) and genotypes -408CT plus TT (P = 0.002) were associated with
      decreased AP risk only in men. The odds ratios for AP in the CC homozygotes
      versus the variant genotypes were 1.95 [95% confidence interval (CI), 0.65-5.85; 
      P = 0.23], 1.72 (95% CI, 0.93-3.20; P = 0.08), and 2.37 (95% CI, 1.09-5.13; P =
      0.03) for men who consumed up to 28, 29 to 59, and more than 60 alcohol drinks a 
      week, respectively. Cigarette smokers with the -408CC genotype had an increased
      risk of AP (odds ratio, 2.07; 95% CI, 1.25-3.42; P = 0.004), whereas nonsmoker
      carriers did not have a disease risk (odds ratio, 1.48; 95% CI, 0.58-3.82; P =
      0.42). CONCLUSIONS: We confirmed a robust association of polymorphism rs10273639 
      at PRSS1-PRSS2 with AP in the Russian population. The present study is the first 
      to show that relationship between the locus and disease is significantly modified
      by alcohol consumption and cigarette smoking.
FAU - Polonikov, Alexey V
AU  - Polonikov AV
AD  - From the *Department of Biology, Medical Genetics and Ecology, daggerResearch
      Institute for Genetic and Molecular Epidemiology, double daggerDepartment of
      Surgical Diseases numero sign2, Kursk State Medical University, Kursk, Russian
      Federation; and section signLaboratory of Genetics, Kursk State University,
      Kursk, Russian Federation.
FAU - Samgina, Tatyana A
AU  - Samgina TA
FAU - Nazarenko, Petr M
AU  - Nazarenko PM
FAU - Bushueva, Olga Y
AU  - Bushueva OY
FAU - Ivanov, Vladimir P
AU  - Ivanov VP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
RN  - 103964-84-7 (PRSS2 protein, human)
RN  - 9002-08-8 (Trypsinogen)
RN  - EC 3.4.21.4 (PRSS1 protein, human)
RN  - EC 3.4.21.4 (Trypsin)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Alcohol Drinking/*adverse effects
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/etiology/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/etiology/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Sex Factors
MH  - Smoking/*adverse effects
MH  - Trypsin/*genetics
MH  - Trypsinogen/*genetics
EDAT- 2016/11/16 06:00
MHDA- 2018/03/07 06:00
CRDT- 2016/11/16 06:00
PHST- 2016/11/16 06:00 [pubmed]
PHST- 2018/03/07 06:00 [medline]
PHST- 2016/11/16 06:00 [entrez]
AID - 10.1097/MPA.0000000000000729 [doi]
PST - ppublish
SO  - Pancreas. 2017 Feb;46(2):230-236. doi: 10.1097/MPA.0000000000000729.