PMID- 27789218
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 197
IP  - 4
DP  - 2017 Apr
TI  - Trends in Testosterone Replacement Therapy Use from 2003 to 2013 among
      Reproductive-Age Men in the United States.
PG  - 1121-1126
LID - S0022-5347(16)31601-9 [pii]
LID - 10.1016/j.juro.2016.10.063 [doi]
AB  - PURPOSE: Although testosterone replacement therapy use in the United States has
      increased dramatically in the last decade, to our knowledge trends in
      testosterone replacement therapy use among reproductive-age men have not been
      investigated. We assessed changes in testosterone replacement therapy use and
      practice patterns among 18 to 45-year-old American men from 2003 to 2013 and
      compared them to older men. MATERIALS AND METHODS: This is a retrospective,
      cross-sectional analysis of men 18 to 45 and 56 to 64 years old who were enrolled
      in the Truven Health MarketScan(R) Commercial Claims Databases throughout each
      given calendar year from 2003 to 2013, including 5,094,868 men in 2013. Trends in
      the yearly rates of testosterone replacement therapy use were calculated using
      Poisson regression. Among testosterone replacement therapy users, the
      Cochran-Armitage test was used to assess temporal trends in age, formulation
      type, semen analysis and serum testosterone level testing during the 12 months
      preceding the documented use of testosterone replacement therapy. RESULTS:
      Between 2003 and 2013, there was a fourfold increase in the rate of testosterone 
      use among 18 to 45-year-old men from 29.2/10,000 person-years to 118.1/10,000
      person-years (p <0.0001). Among testosterone replacement therapy users, topical
      gel formulations were initially most used. Injection use then doubled between
      2009 and 2012 (23.5% and 46.2%, respectively) and surpassed topical gel use in
      2013. In men 56 to 64 years old there was a statistically significant threefold
      increase in testosterone replacement therapy use (p <0.0001), which was
      significantly smaller than the fourfold increase in younger men (p <0.0001).
      CONCLUSIONS: In 2003 to 2013, testosterone replacement therapy use increased
      fourfold in men 18 to 45 years old compared to threefold in older men. This
      younger age group should be a focus for future studies due to effects on
      fertility and unknown long-term sequelae.
CI  - Copyright (c) 2017 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Rao, Pravin Kumar
AU  - Rao PK
AD  - Mid Atlantic Permanente Medical Group, Baltimore, Maryland.
FAU - Boulet, Sheree L
AU  - Boulet SL
AD  - Centers for Disease Control and Prevention, Atlanta, Georgia.
FAU - Mehta, Akanksha
AU  - Mehta A
AD  - Department of Urology, Emory University, Atlanta, Georgia.
FAU - Hotaling, James
AU  - Hotaling J
AD  - Division of Urology, University of Utah, Salt Lake City, Utah.
FAU - Eisenberg, Michael L
AU  - Eisenberg ML
AD  - Department of Urology, Stanford University, Palo Alto, California.
FAU - Honig, Stanton C
AU  - Honig SC
AD  - Department of Urology, Yale University, New Haven, Connecticut.
FAU - Warner, Lee
AU  - Warner L
AD  - Centers for Disease Control and Prevention, Atlanta, Georgia.
FAU - Kissin, Dmitry M
AU  - Kissin DM
AD  - Centers for Disease Control and Prevention, Atlanta, Georgia.
FAU - Nangia, Ajay K
AU  - Nangia AK
AD  - Department of Urology, University of Kansas, Kansas City, Kansas.
FAU - Ross, Lawrence S
AU  - Ross LS
AD  - Department of Urology, University of Illinois, Chicago, Illinois. Electronic
      address: lsross51941@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20161024
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 3XMK78S47O (Testosterone)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Cross-Sectional Studies
MH  - Hormone Replacement Therapy/*trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Practice Patterns, Physicians'
MH  - Retrospective Studies
MH  - Testosterone/*therapeutic use
MH  - Time Factors
MH  - United States
MH  - *Urology
MH  - Young Adult
OTO - NOTNLM
OT  - *age groups
OT  - *hypogonadism
OT  - *infertility
OT  - *male
OT  - *testis
OT  - *testosterone
EDAT- 2016/10/30 06:00
MHDA- 2019/03/12 06:00
CRDT- 2016/10/30 06:00
PHST- 2016/10/19 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2016/10/30 06:00 [entrez]
AID - S0022-5347(16)31601-9 [pii]
AID - 10.1016/j.juro.2016.10.063 [doi]
PST - ppublish
SO  - J Urol. 2017 Apr;197(4):1121-1126. doi: 10.1016/j.juro.2016.10.063. Epub 2016 Oct
      24.