PMID- 27777055
OWN - NLM
STAT- MEDLINE
DCOM- 20170919
LR  - 20170919
IS  - 1873-4588 (Electronic)
IS  - 0892-1997 (Linking)
VI  - 31
IP  - 2
DP  - 2017 Mar
TI  - Laboratory Evaluation of Vocal Fold Paralysis and Paresis.
PG  - 168-174
LID - S0892-1997(16)30224-7 [pii]
LID - 10.1016/j.jvoice.2016.07.022 [doi]
AB  - OBJECTIVES: This study aimed to assess the value of comprehensive laboratory
      evaluation in patients with vocal fold paralysis or paresis. STUDY DESIGN: This
      is a retrospective chart review. METHODS: Records of 231 patients with vocal fold
      paralysis or paresis were reviewed to determine whether there is a significant
      increase in the number of abnormal test results compared with rates of abnormal
      results for these tests in the general population and whether testing resulted in
      clinically important diagnosis. Laboratory data were collected from charts from
      initial visits from 2010 to 2014 and compared with national data. RESULTS: When
      controlled for age and sex, white blood cell count was found to have a
      significantly higher rate of abnormal test results (P < 0.001) in patients with
      vocal fold paralysis or paresis than the general population. Although hemoglobin,
      thyroid-stimulating hormone, and thyroid antibody tests were more likely to be
      abnormal in our patient population, the trend was not statistically significant. 
      Further, the prevalence of syphilis and myasthenia gravis was found to be higher 
      in these subjects than their respective national prevalences, and the incidence
      of Lyme disease was found to be higher than the national prevalence of Lyme
      disease. Several patients were diagnosed with medically important conditions such
      as diabetes, thyroid dysfunction, syphilis, myasthenia gravis, and Lyme disease
      based on these tests. CONCLUSION: This study suggests that comprehensive testing 
      of patients with vocal fold movement disorders results in diagnoses that would be
      missed without a comprehensive evaluation, some of which are important medically,
      although their causal relationship to vocal fold paralysis or paresis was not
      investigated or established.
CI  - Copyright (c) 2017 The Voice Foundation. Published by Elsevier Inc. All rights
      reserved.
FAU - White, Michelle
AU  - White M
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, Pennsylvania.
FAU - Meenan, Kirsten
AU  - Meenan K
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, Pennsylvania.
FAU - Patel, Tirth
AU  - Patel T
AD  - Department of Radiology, University of North Carolina School of Medicine, Chapel 
      Hill, North Carolina.
FAU - Jaworek, Aaron
AU  - Jaworek A
AD  - Department of Otolaryngology-Head and Neck Surgery, Drexel University College of 
      Medicine, Philadelphia, Pennsylvania.
FAU - Sataloff, Robert T
AU  - Sataloff RT
AD  - Department of Otolaryngology-Head and Neck Surgery, Clinical Academic
      Specialties, Drexel University College of Medicine, Philadelphia, Pennsylvania.
      Electronic address: journal@voicefoundation.org.
LA  - eng
PT  - Journal Article
DEP - 20161021
PL  - United States
TA  - J Voice
JT  - Journal of voice : official journal of the Voice Foundation
JID - 8712262
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Dysphonia/*diagnosis/physiopathology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Leukocyte Count
MH  - Lyme Disease/diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/epidemiology
MH  - Philadelphia/epidemiology
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Serologic Tests
MH  - Severity of Illness Index
MH  - Syphilis/diagnosis/epidemiology
MH  - Vocal Cord Paralysis/blood/*diagnosis/epidemiology/physiopathology
MH  - Vocal Cords/*physiopathology
MH  - *Voice Quality
OTO - NOTNLM
OT  - Blood tests
OT  - Dysphonia
OT  - Hoarseness
OT  - Laboratory tests
OT  - Vocal fold paralysis
OT  - Vocal fold paresis
OT  - Work-up for dysphonia
EDAT- 2016/10/26 06:00
MHDA- 2017/09/20 06:00
CRDT- 2016/10/26 06:00
PHST- 2016/06/09 00:00 [received]
PHST- 2016/07/25 00:00 [revised]
PHST- 2016/07/26 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2017/09/20 06:00 [medline]
PHST- 2016/10/26 06:00 [entrez]
AID - S0892-1997(16)30224-7 [pii]
AID - 10.1016/j.jvoice.2016.07.022 [doi]
PST - ppublish
SO  - J Voice. 2017 Mar;31(2):168-174. doi: 10.1016/j.jvoice.2016.07.022. Epub 2016 Oct
      21.