PMID- 27770258
OWN - NLM
STAT- MEDLINE
DCOM- 20180227
LR  - 20180801
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 32
IP  - 3
DP  - 2017 Mar
TI  - Kidney transplantation fails to provide adequate growth in children with chronic 
      kidney disease born small for gestational age.
PG  - 511-519
LID - 10.1007/s00467-016-3503-5 [doi]
AB  - BACKGROUND: Children with chronic kidney disease are frequently born small for
      gestational age (SGA) and prone to disproportionately short stature. It is
      unclear how SGA affects growth after kidney transplantation (KTx). METHODS:
      Linear growth (height, sitting height, and leg length) was prospectively
      investigated in a cohort of 322 pediatric KTx recipients, with a mean follow-up
      of 4.9 years. Sitting height index (ratio of sitting height to total body height)
      was used to assess body proportions. Predictors of growth outcome in KTx patients
      with (n = 94) and without (n = 228) an SGA history were evaluated by the use of
      linear mixed-effects models. RESULTS: Mean z-scores for all linear body
      dimensions were lower in SGA compared with non-SGA patients (p < 0.001). SGA
      patients presented with higher target height deficit and degree of body
      disproportion (p < 0.001). The latter was mainly due to reduced leg growth during
      childhood. Pubertal trunk growth was diminished in SGA patients, and the pubertal
      growth spurt of legs was delayed in both groups, resulting in further impairment 
      of adult height, which was more frequently reduced in SGA than in non-SGA
      patients (50 % vs 18 %, p < 0.001). Use of growth hormone treatment in the
      pre-transplant period, preemptive KTx, transplant function, and control of
      metabolic acidosis were the only potentially modifiable correlates of
      post-transplant growth in SGA groups. By contrast, living related KTx, steroid
      exposure, and degree of anemia proved to be correlates in non-SGA only.
      CONCLUSIONS: In children born SGA, growth outcome after KTx is significantly more
      impaired and affected by different clinical parameters compared with non-SGA
      patients.
FAU - Franke, Doris
AU  - Franke D
AD  - Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's
      Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover,
      Germany.
FAU - Steffens, Rena
AU  - Steffens R
AD  - Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's
      Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover,
      Germany.
FAU - Thomas, Lena
AU  - Thomas L
AD  - Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's
      Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover,
      Germany.
FAU - Pavicic, Leo
AU  - Pavicic L
AD  - , Rendiceva 28B, 10000, Zagreb, Croatia.
FAU - Ahlenstiel, Thurid
AU  - Ahlenstiel T
AD  - Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's
      Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover,
      Germany.
FAU - Pape, Lars
AU  - Pape L
AD  - Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's
      Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover,
      Germany.
FAU - Gellermann, Jutta
AU  - Gellermann J
AD  - Department of Pediatric Nephrology, Charite University Hospital, Augustenburger
      Platz 1, 13353, Berlin, Germany.
FAU - Muller, Dominik
AU  - Muller D
AD  - Department of Pediatric Nephrology, Charite University Hospital, Augustenburger
      Platz 1, 13353, Berlin, Germany.
FAU - Querfeld, Uwe
AU  - Querfeld U
AD  - Department of Pediatric Nephrology, Charite University Hospital, Augustenburger
      Platz 1, 13353, Berlin, Germany.
FAU - Haffner, Dieter
AU  - Haffner D
AD  - Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's
      Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover,
      Germany.
FAU - Zivicnjak, Miroslav
AU  - Zivicnjak M
AD  - Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's
      Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover,
      Germany. zivicnjak.miroslav@mh-hannover.de.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20161021
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
SB  - IM
MH  - Adolescent
MH  - Aging
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Growth
MH  - Growth Disorders/*etiology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age
MH  - Kidney Transplantation/*methods
MH  - Leg/growth & development
MH  - Linear Models
MH  - Male
MH  - Prospective Studies
MH  - Renal Insufficiency, Chronic/complications/pathology/*surgery
MH  - Sexual Maturation
MH  - Thorax/growth & development
OTO - NOTNLM
OT  - *Anthropometry
OT  - *Children
OT  - *Chronic kidney disease
OT  - *Growth
OT  - *Kidney transplantation
OT  - *Small for gestational age
EDAT- 2016/10/23 06:00
MHDA- 2018/02/28 06:00
CRDT- 2016/10/23 06:00
PHST- 2016/05/18 00:00 [received]
PHST- 2016/08/22 00:00 [accepted]
PHST- 2016/08/19 00:00 [revised]
PHST- 2016/10/23 06:00 [pubmed]
PHST- 2018/02/28 06:00 [medline]
PHST- 2016/10/23 06:00 [entrez]
AID - 10.1007/s00467-016-3503-5 [doi]
AID - 10.1007/s00467-016-3503-5 [pii]
PST - ppublish
SO  - Pediatr Nephrol. 2017 Mar;32(3):511-519. doi: 10.1007/s00467-016-3503-5. Epub
      2016 Oct 21.