PMID- 27746043
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20180312
IS  - 1873-4588 (Electronic)
IS  - 0892-1997 (Linking)
VI  - 31
IP  - 3
DP  - 2017 May
TI  - Brain Activity in Patients With Adductor Spasmodic Dysphonia Detected by
      Functional Magnetic Resonance Imaging.
PG  - 379.e1-379.e11
LID - S0892-1997(16)30304-6 [pii]
LID - 10.1016/j.jvoice.2016.09.018 [doi]
AB  - OBJECTIVES: Spasmodic dysphonia (SD) is considered a focal dystonia. However, the
      detailed pathophysiology of SD remains unclear, despite the detection of abnormal
      activity in several brain regions. The aim of this study was to clarify the
      pathophysiological background of SD. STUDY DESIGN: This is a case-control study. 
      METHODS: Both task-related brain activity measured by functional magnetic
      resonance imaging by reading the five-digit numbers and resting-state functional 
      connectivity (FC) measured by 150 T2-weighted echo planar images acquired without
      any task were investigated in 12 patients with adductor SD and in 16 healthy
      controls. RESULTS: The patients with SD showed significantly higher task-related 
      brain activation in the left middle temporal gyrus, left thalamus, bilateral
      primary motor area, bilateral premotor area, bilateral cerebellum, bilateral
      somatosensory area, right insula, and right putamen compared with the controls.
      Region of interest voxel FC analysis revealed many FC changes within the
      cerebellum-basal ganglia-thalamus-cortex loop in the patients with SD. Of the
      significant connectivity changes between the patients with SD and the controls,
      the FC between the left thalamus and the left caudate nucleus was significantly
      correlated with clinical parameters in SD. CONCLUSION: The higher task-related
      brain activity in the insula and cerebellum was consistent with previous
      neuroimaging studies, suggesting that these areas are one of the unique
      characteristics of phonation-induced brain activity in SD. Based on FC analysis
      and their significant correlations with clinical parameters, the basal ganglia
      network plays an important role in the pathogenesis of SD.
CI  - Copyright (c) 2017 The Voice Foundation. Published by Elsevier Inc. All rights
      reserved.
FAU - Kiyuna, Asanori
AU  - Kiyuna A
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan.
FAU - Kise, Norimoto
AU  - Kise N
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan.
FAU - Hiratsuka, Munehisa
AU  - Hiratsuka M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan.
FAU - Kondo, Shunsuke
AU  - Kondo S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan.
FAU - Uehara, Takayuki
AU  - Uehara T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan.
FAU - Maeda, Hiroyuki
AU  - Maeda H
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan.
FAU - Ganaha, Akira
AU  - Ganaha A
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan.
FAU - Suzuki, Mikio
AU  - Suzuki M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of
      Medicine, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215,
      Japan. Electronic address: suzuki@med.u-ryukyu.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20161013
PL  - United States
TA  - J Voice
JT  - Journal of voice : official journal of the Voice Foundation
JID - 8712262
SB  - IM
MH  - Adult
MH  - Aged
MH  - Basal Ganglia/diagnostic imaging/physiopathology
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Brain Mapping/*methods
MH  - Case-Control Studies
MH  - Cerebellum/diagnostic imaging/physiopathology
MH  - Cerebral Cortex/diagnostic imaging/physiopathology
MH  - Dysphonia/*diagnostic imaging/physiopathology
MH  - Female
MH  - Humans
MH  - Laryngeal Muscles/*physiopathology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Phonation
MH  - Predictive Value of Tests
MH  - Voice Quality
MH  - Young Adult
OTO - NOTNLM
OT  - Basal ganglia network
OT  - Disease severity
OT  - Focal dystonia
OT  - Resting-state functional connectivity
OT  - Spasmodic dysphonia
EDAT- 2016/10/18 06:00
MHDA- 2018/03/13 06:00
CRDT- 2016/10/18 06:00
PHST- 2016/08/04 00:00 [received]
PHST- 2016/09/15 00:00 [revised]
PHST- 2016/09/16 00:00 [accepted]
PHST- 2016/10/18 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
PHST- 2016/10/18 06:00 [entrez]
AID - S0892-1997(16)30304-6 [pii]
AID - 10.1016/j.jvoice.2016.09.018 [doi]
PST - ppublish
SO  - J Voice. 2017 May;31(3):379.e1-379.e11. doi: 10.1016/j.jvoice.2016.09.018. Epub
      2016 Oct 13.