PMID- 27743393
OWN - NLM
STAT- MEDLINE
DCOM- 20170914
LR  - 20170914
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 44
IP  - 4
DP  - 2017 Apr
TI  - Adjuvant alternative treatment with chemical peeling and subsequent iontophoresis
      for postinflammatory hyperpigmentation, erosion with inflamed red papules and
      non-inflamed atrophic scars in acne vulgaris.
PG  - 401-405
LID - 10.1111/1346-8138.13634 [doi]
AB  - The standard management of acne vulgaris in Japan includes a combination of
      topical treatment with benzoyl peroxide (BPO) and BPO/clindamycin (CLDM), topical
      adapalene and systemic antimicrobials. However, the treatment of
      therapy-resistant complications such as postinflammatory hyperpigmentation (PIH),
      erosions with inflamed red papules and atrophic scars has not been established.
      We performed chemical peeling with glycolic acid and iontophoresis with ascorbyl 
      2-phosphate 6-palmitate and DL-alpha-tocopherol phosphate for the treatment of
      PIH, erosions with inflamed red papules and non-inflamed atrophic scars in 31
      patients with acne vulgaris (mild to severe severity), and evaluated the efficacy
      and safety of these interventions. In most of cases, there was remarkable
      improvement in PIH and erosions with inflamed red papules after treatment. There 
      was also some improvement in non-inflamed atrophic scars without erythema. Mild
      redness and irritation was observed in four cases as adverse reactions. Early
      initial treatment of PIH and erosions with red papules by chemical peeling and
      iontophoresis is an effective and safe method to prevent the formation of
      atrophic scars in patients with acne vulgaris.
CI  - (c) 2016 Japanese Dermatological Association.
FAU - Kurokawa, Ichiro
AU  - Kurokawa I
AD  - Department of Dermatology and Acne Clinical Research Center, Meiwa Hospital,
      Nishinomiya, Japan.
FAU - Oiso, Naoki
AU  - Oiso N
AD  - Department of Dermatology, Faculty of Medicine, Kinki University, Osaka, Japan.
FAU - Kawada, Akira
AU  - Kawada A
AD  - Department of Dermatology, Faculty of Medicine, Kinki University, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161015
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (6-O-palmitol-ascorbate-2-O-phosphate)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Glycolates)
RN  - 0WT12SX38S (glycolic acid)
RN  - 1L4806J2QF (Adapalene)
RN  - 38976-17-9 (alpha-tocopherol phosphate)
RN  - 3U02EL437C (Clindamycin)
RN  - H4N855PNZ1 (alpha-Tocopherol)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - W9WZN9A0GM (Benzoyl Peroxide)
SB  - IM
MH  - Acne Vulgaris/*complications/*therapy
MH  - Adapalene/therapeutic use
MH  - Adolescent
MH  - Adult
MH  - Anti-Infective Agents/therapeutic use
MH  - Ascorbic Acid/administration & dosage/adverse effects/analogs &
      derivatives/therapeutic use
MH  - Atrophy
MH  - Benzoyl Peroxide/therapeutic use
MH  - Chemexfoliation/*adverse effects
MH  - Cicatrix/pathology/*therapy
MH  - Clindamycin/therapeutic use
MH  - Combined Modality Therapy
MH  - Erythema/*therapy
MH  - Female
MH  - Glycolates/administration & dosage/adverse effects/therapeutic use
MH  - Humans
MH  - Hyperpigmentation/*therapy
MH  - Iontophoresis/*adverse effects
MH  - Japan
MH  - Male
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Young Adult
MH  - alpha-Tocopherol/administration & dosage/adverse effects/analogs &
      derivatives/therapeutic use
OTO - NOTNLM
OT  - acne
OT  - atrophic scar
OT  - chemical peeling
OT  - iontophoresis
OT  - postinflammatory hyperpigmentation
EDAT- 2016/10/16 06:00
MHDA- 2017/09/15 06:00
CRDT- 2016/10/16 06:00
PHST- 2016/08/03 00:00 [received]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/10/16 06:00 [pubmed]
PHST- 2017/09/15 06:00 [medline]
PHST- 2016/10/16 06:00 [entrez]
AID - 10.1111/1346-8138.13634 [doi]
PST - ppublish
SO  - J Dermatol. 2017 Apr;44(4):401-405. doi: 10.1111/1346-8138.13634. Epub 2016 Oct
      15.