PMID- 27737740
OWN - NLM
STAT- MEDLINE
DCOM- 20170628
LR  - 20170628
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 68
IP  - 16
DP  - 2016 Oct 18
TI  - Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical
      Unloading.
PG  - 1741-1752
LID - S0735-1097(16)34925-7 [pii]
LID - 10.1016/j.jacc.2016.07.756 [doi]
AB  - BACKGROUND: Small-scale studies focused mainly on nonischemic cardiomyopathy
      (NICM) have shown that a subset of left ventricular assist device (LVAD) patients
      can achieve significant improvement of their native heart function, but the
      impact of ischemic cardiomyopathy (ICM) has not been specifically investigated.
      Many patients with acute myocardial infarction are discharged from their index
      hospitalization without heart failure (HF), only to return much later with overt 
      HF syndrome, mainly caused by chronic remodeling of the noninfarcted region of
      the myocardium. OBJECTIVES: This study sought to prospectively investigate the
      effect of ICM HF etiology on LVAD-associated improvement of cardiac structure and
      function using NICM as control. METHODS: Consecutive patients (n = 154) with
      documented chronic and dilated cardiomyopathy (ICM, n = 61; NICM, n = 93)
      requiring durable support with continuous-flow LVAD were prospectively evaluated 
      with serial echocardiograms and right heart catheterizations. RESULTS: In
      patients supported with LVAD for at least 6 months, we found that 5% of subjects 
      with ICM and 21% of subjects with NICM achieved left ventricular ejection
      fraction >/=40% (p = 0.034). LV end-diastolic and end-systolic volumes and
      diastolic function were significantly and similarly improved in patients with ICM
      and NICM. CONCLUSIONS: LVAD-associated unloading for 6 months resulted in a
      substantial improvement in myocardial structure, and systolic and diastolic
      function in 1 in 20 ICM and 1 in 5 NICM patients. These specific incidence and
      timeline findings may provide guidance in clinical practice and research design
      for sequencing and prioritizing advanced HF and heart transplantation therapeutic
      options in patients with ICM and NICM.
CI  - Copyright (c) 2016 American College of Cardiology Foundation. Published by
      Elsevier Inc. All rights reserved.
FAU - Wever-Pinzon, James
AU  - Wever-Pinzon J
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Selzman, Craig H
AU  - Selzman CH
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah; University of Utah
      Molecular Medicine Program, Salt Lake City, Utah.
FAU - Stoddard, Greg
AU  - Stoddard G
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Wever-Pinzon, Omar
AU  - Wever-Pinzon O
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Catino, Anna
AU  - Catino A
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Kfoury, Abdallah G
AU  - Kfoury AG
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Diakos, Nikolaos A
AU  - Diakos NA
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah; University of Utah
      Molecular Medicine Program, Salt Lake City, Utah.
FAU - Reid, Bruce B
AU  - Reid BB
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - McKellar, Stephen
AU  - McKellar S
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah; University of Utah
      Molecular Medicine Program, Salt Lake City, Utah.
FAU - Bonios, Michael
AU  - Bonios M
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Koliopoulou, Antigone
AU  - Koliopoulou A
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Budge, Deborah
AU  - Budge D
AD  - University of Utah Molecular Medicine Program, Salt Lake City, Utah.
FAU - Kelkhoff, Aaron
AU  - Kelkhoff A
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Stehlik, Josef
AU  - Stehlik J
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Fang, James C
AU  - Fang JC
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah.
FAU - Drakos, Stavros G
AU  - Drakos SG
AD  - Utah Transplantation Affiliated Hospitals Cardiac Transplant Program, University 
      of Utah Health Sciences Center, Intermountain Medical Center, Veterans Affairs
      Salt Lake City Health Care System, Salt Lake City, Utah; University of Utah
      Molecular Medicine Program, Salt Lake City, Utah. Electronic address:
      stavros.drakos@hsc.utah.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - AIM
SB  - IM
CIN - J Am Coll Cardiol. 2016 Oct 18;68(16):1753-1755. PMID: 27737741
MH  - Female
MH  - Heart/anatomy & histology/physiology
MH  - Heart Failure/*etiology/*therapy
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardial Ischemia/*complications
MH  - Prospective Studies
MH  - Recovery of Function
OTO - NOTNLM
OT  - cardiac recovery
OT  - ischemic cardiomyopathy
OT  - left ventricular assist device
OT  - mechanical unloading
OT  - myocardial function
OT  - myocardial structure
EDAT- 2016/10/16 06:00
MHDA- 2017/06/29 06:00
CRDT- 2016/10/15 06:00
PHST- 2016/04/12 00:00 [received]
PHST- 2016/07/07 00:00 [revised]
PHST- 2016/07/12 00:00 [accepted]
PHST- 2016/10/15 06:00 [entrez]
PHST- 2016/10/16 06:00 [pubmed]
PHST- 2017/06/29 06:00 [medline]
AID - S0735-1097(16)34925-7 [pii]
AID - 10.1016/j.jacc.2016.07.756 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2016 Oct 18;68(16):1741-1752. doi: 10.1016/j.jacc.2016.07.756.