PMID- 27697577
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20190305
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 197
IP  - 3 Pt 1
DP  - 2017 Mar
TI  - Association of Sleep Disordered Breathing with Erectile Dysfunction in Community 
      Dwelling Older Men.
PG  - 776-782
LID - S0022-5347(16)31408-2 [pii]
LID - 10.1016/j.juro.2016.09.089 [doi]
AB  - PURPOSE: We investigated the association between sleep disordered breathing and
      erectile dysfunction in older men. MATERIALS AND METHODS: We performed a
      cross-sectional analysis of community dwelling men age 67 years or older enrolled
      in the Osteoporotic Fractures in Men Sleep Study. Participants underwent
      overnight polysomnography (2003 to 2005) and completed sexual health
      questionnaires (2005 to 2006). We defined sleep disordered breathing using the
      apnea-hypopnea index or nocturnal hypoxemia. Erectile dysfunction was defined
      using the MMAS (Massachusetts Male Aging Study) scale and, in sexually active
      men, the International Index of Erectile Function. We used logistic regression to
      examine the association between sleep disordered breathing and erectile
      dysfunction. RESULTS: Mean participant age was 76+/-5 years. Of the 2,676 men
      completing the MMAS, 70% had moderate to complete erectile dysfunction. Among
      1,099 sexually active men completing the IIEF-5 (5-item International Index of
      Erectile Function), 26% had moderate to severe erectile dysfunction. A higher
      apnea-hypopnea index was associated with greater odds of MMAS defined moderate to
      complete erectile dysfunction after adjusting for age and study site (OR 1.39,
      95% CI 1.00-1.92 for severe sleep disordered breathing vs none, p trend=0.008),
      but not after further adjustment for body mass index, socioeconomic status and
      comorbidities (OR 1.05, 95% CI 0.75-1.49, p trend=0.452). Greater nocturnal
      hypoxemia was associated with increased odds of MMAS defined moderate to complete
      erectile dysfunction (unadjusted OR 1.36, 95% Cl 1.04-1.80 vs none) but this was 
      attenuated after adjustment for age and study site (OR 1.24, 95% CI 0.92-1.66).
      Sleep disordered breathing was not associated with erectile dysfunction by 5-item
      International Index of Erectile Function. CONCLUSIONS: In this cross-sectional
      analysis in older men sleep disordered breathing was associated with higher odds 
      of erectile dysfunction in unadjusted analyses that was largely explained by
      higher body mass index and increased comorbidity among men with sleep disordered 
      breathing. Prospective studies accounting for obesity and multimorbidity would
      further clarify the association of sleep disordered breathing and erectile
      dysfunction.
CI  - Copyright (c) 2017 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Bozorgmehri, Shahab
AU  - Bozorgmehri S
AD  - Department of Epidemiology, College of Public Health and Health Professions &
      College of Medicine, University of Florida, and Malcom-Randall VAMC, Gainesville,
      Florida. Electronic address: s.bozorgmehri@ufl.edu.
FAU - Fink, Howard A
AU  - Fink HA
AD  - Department of Medicine, and Division of Epidemiology & Community Health, School
      of Public Health, University of Minnesota, Minneapolis, Minnesota; Center for
      Chronic Disease Outcomes Research, Veterans Affairs Health System, Minneapolis,
      Minnesota; Geriatric Research Education and Clinical Center, Veterans Affairs
      Health System, Minneapolis, Minnesota.
FAU - Parimi, Neeta
AU  - Parimi N
AD  - California Pacific Medical Center Research Institute, San Francisco, California.
FAU - Canales, Benjamin
AU  - Canales B
AD  - Department of Urology, College of Public Health and Health Professions & College 
      of Medicine, University of Florida, and Malcom-Randall VAMC, Gainesville,
      Florida.
FAU - Ensrud, Kristine E
AU  - Ensrud KE
AD  - Department of Medicine, and Division of Epidemiology & Community Health, School
      of Public Health, University of Minnesota, Minneapolis, Minnesota; Center for
      Chronic Disease Outcomes Research, Veterans Affairs Health System, Minneapolis,
      Minnesota.
FAU - Ancoli-Israel, Sonia
AU  - Ancoli-Israel S
AD  - Departments of Psychiatry and Medicine, University of California, San Diego, La
      Jolla, California.
FAU - Canales, Muna
AU  - Canales M
AD  - Department of Medicine (Nephrology), College of Public Health and Health
      Professions & College of Medicine, University of Florida, and Malcom-Randall
      VAMC, Gainesville, Florida.
CN  - MrOS Study
LA  - eng
GR  - R01 HL070848/HL/NHLBI NIH HHS/United States
GR  - R01 HL071194/HL/NHLBI NIH HHS/United States
GR  - R01 HL070847/HL/NHLBI NIH HHS/United States
GR  - R01 HL070842/HL/NHLBI NIH HHS/United States
GR  - U01 AG042124/AG/NIA NIH HHS/United States
GR  - U01 AG042145/AG/NIA NIH HHS/United States
GR  - U01 AG042168/AG/NIA NIH HHS/United States
GR  - R01 HL070841/HL/NHLBI NIH HHS/United States
GR  - U01 AG042140/AG/NIA NIH HHS/United States
GR  - R01 HL070838/HL/NHLBI NIH HHS/United States
GR  - R01 HL070839/HL/NHLBI NIH HHS/United States
GR  - U01 AG027810/AG/NIA NIH HHS/United States
GR  - R01 HL070837/HL/NHLBI NIH HHS/United States
GR  - U01 AG042143/AG/NIA NIH HHS/United States
GR  - U01 AG042139/AG/NIA NIH HHS/United States
GR  - U01 AR066160/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20160930
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - AIM
SB  - IM
CIN - J Urol. 2017 Mar;197(3 Pt 1):782. PMID: 27992747
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Erectile Dysfunction/*epidemiology
MH  - Humans
MH  - Independent Living
MH  - Male
MH  - Polysomnography
MH  - Sleep Apnea Syndromes/*complications/diagnosis
PMC - PMC5374724
MID - NIHMS847355
OTO - NOTNLM
OT  - *erectile dysfunction
OT  - *sleep apnea syndromes
EDAT- 2016/10/05 06:00
MHDA- 2019/03/06 06:00
CRDT- 2016/10/05 06:00
PHST- 2016/09/20 00:00 [accepted]
PHST- 2016/10/05 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2016/10/05 06:00 [entrez]
AID - S0022-5347(16)31408-2 [pii]
AID - 10.1016/j.juro.2016.09.089 [doi]
PST - ppublish
SO  - J Urol. 2017 Mar;197(3 Pt 1):776-782. doi: 10.1016/j.juro.2016.09.089. Epub 2016 
      Sep 30.