PMID- 27687848
OWN - NLM
STAT- MEDLINE
DCOM- 20170524
LR  - 20181113
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 151
IP  - 2
DP  - 2017 Feb
TI  - Association of Sarcoidosis With Increased Risk of VTE: A Population-Based Study, 
      1976 to 2013.
PG  - 425-430
LID - S0012-3692(16)59247-2 [pii]
LID - 10.1016/j.chest.2016.09.009 [doi]
AB  - OBJECTIVE: The goal of this study was to investigate the risk of VTE among
      patients with sarcoidosis. METHODS: A cohort of 345 incident cases of sarcoidosis
      and 345 sex- and age-matched comparator subjects in Olmsted County, Minnesota,
      from 1976 to 2013 were identified from the comprehensive medical record linkage
      system. Medical records were reviewed for DVT and pulmonary embolism (PE). The
      cumulative incidence was estimated, adjusted for the competing risk of death. Cox
      proportional hazards models were used to compare the rate of development of these
      events between patients with sarcoidosis and the nonsarcoidosis comparison
      cohort. RESULTS: The prevalence of VTE, DVT, and PE prior to the index date was
      not significantly different between case and comparator subjects. The risk of
      incident VTE adjusted for age, sex, and calendar year was significantly higher
      among patients with sarcoidosis (hazard ratio [HR], 3.04 [95% CI, 1.47-6.29]).
      Significantly elevated risk was observed in both subtypes of VTE, with an HR of
      3.14 (95% CI, 1.32-7.48) for DVT and an HR of 4.29 (95% CI, 1.21-15.23) for PE. A
      sensitivity analysis including only VTE events that occurred at least 6 months
      after the index date adjusted for age, sex, and calendar year revealed somewhat
      lower HRs: VTE, 2.73 (95% CI, 1.30-5.72); DVT, 3.00 (95% CI, 1.25-7.20); and PE, 
      3.58 (95% CI, 0.98-13.03). CONCLUSIONS: An increased risk of VTE among patients
      with sarcoidosis was observed in this population-based cohort.
CI  - Copyright (c) 2016 American College of Chest Physicians. Published by Elsevier
      Inc. All rights reserved.
FAU - Ungprasert, Patompong
AU  - Ungprasert P
AD  - Division of Rheumatology, Department of Internal Medicine, Mayo Clinic,
      Rochester, MN. Electronic address: p.ungprasert@gmail.com.
FAU - Crowson, Cynthia S
AU  - Crowson CS
AD  - Division of Rheumatology, Department of Internal Medicine, Mayo Clinic,
      Rochester, MN; Division of Biomedical Statistics and Informatics, Department of
      Health Science Research, Mayo Clinic, Rochester, MN.
FAU - Matteson, Eric L
AU  - Matteson EL
AD  - Division of Rheumatology, Department of Internal Medicine, Mayo Clinic,
      Rochester, MN; Division of Epidemiology, Department of Health Science Research,
      Mayo Clinic, Rochester, MN.
LA  - eng
GR  - R01 AG034676/AG/NIA NIH HHS/United States
GR  - R01 AR030582/AR/NIAMS NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, N.I.H., Extramural
DEP - 20160928
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - AIM
SB  - IM
CIN - Chest. 2017 Jun;151(6):1398-1399. PMID: 28599933
CIN - Chest. 2017 Jun;151(6):1399. PMID: 28599935
MH  - Adult
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Minnesota/epidemiology
MH  - Proportional Hazards Models
MH  - Pulmonary Embolism/*epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sarcoidosis/epidemiology
MH  - Sarcoidosis, Pulmonary/*epidemiology
MH  - Venous Thromboembolism/epidemiology
MH  - Venous Thrombosis/*epidemiology
PMC - PMC5310113
OTO - NOTNLM
OT  - *DVT
OT  - *VTE
OT  - *epidemiology
OT  - *pulmonary embolism
OT  - *sarcoidosis
EDAT- 2016/10/01 06:00
MHDA- 2017/05/26 06:00
CRDT- 2016/10/01 06:00
PHST- 2016/07/12 00:00 [received]
PHST- 2016/08/04 00:00 [revised]
PHST- 2016/09/09 00:00 [accepted]
PHST- 2016/10/01 06:00 [pubmed]
PHST- 2017/05/26 06:00 [medline]
PHST- 2016/10/01 06:00 [entrez]
AID - S0012-3692(16)59247-2 [pii]
AID - 10.1016/j.chest.2016.09.009 [doi]
PST - ppublish
SO  - Chest. 2017 Feb;151(2):425-430. doi: 10.1016/j.chest.2016.09.009. Epub 2016 Sep
      28.