PMID- 27686489
OWN - NLM
STAT- MEDLINE
DCOM- 20170927
LR  - 20180911
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 37
IP  - 12
DP  - 2016 Dec
TI  - Comparison of Quantitative Cerebral Blood Flow Measurements Performed by Bookend 
      Dynamic Susceptibility Contrast and Arterial Spin-Labeling MRI in
      Relapsing-Remitting Multiple Sclerosis.
PG  - 2265-2272
AB  - BACKGROUND AND PURPOSE: Quantitative CBF usage as a biomarker for cognitive
      impairment and disease progression in MS is potentially a powerful tool for
      longitudinal patient monitoring. Dynamic susceptibility contrast perfusion with
      bookend T1-calibration (bookend technique) and pseudocontinuous arterial
      spin-labeling have recently been used for CBF quantification in
      relapsing-remitting MS. The noninvasive nature of pseudocontinuous arterial
      spin-labeling is advantageous over gadolinium-based techniques, but correlation
      between the techniques is not well-established in the context of MS. MATERIALS
      AND METHODS: We compared pseudocontinuous arterial spin-labeling CBF with the
      bookend technique in a prospective cohort of 19 healthy controls, 19 subjects
      with relapsing-remitting MS without cognitive impairment, and 20 subjects with
      relapsing-remitting MS with cognitive impairment on a voxelwise and Brodmann
      region basis. The linear Pearson correlation, SNR, and coefficient of variation
      were quantified. RESULTS: Voxelwise paired t tests revealed no significant CBF
      differences between techniques after normalization of global mean intensities.
      The highest Pearson correlations were observed in deep GM structures (average r =
      0.71 for the basal ganglia and r = 0.65 for the thalamus) but remained robust for
      cortical GM, WM, and white matter lesions (average r = 0.51, 0.53, 0.54,
      respectively). Lower Pearson correlations were observed for cortical lesions
      (average r = 0.23). Brodmann region correlations were significant for all groups.
      All correlations were maintained in healthy controls and in patients with
      relapsing-remitting multiple sclerosis. The highest SNR was present in bookend
      perfusion, while the highest coefficient of variation was present in white matter
      lesions. CONCLUSIONS: Agreement between pseudocontinuous arterial spin-labeling
      and bookend technique CBF measurements is demonstrated in healthy controls and
      patients with relapsing-remitting MS.
CI  - (c) 2016 by American Journal of Neuroradiology.
FAU - D'Ortenzio, R M
AU  - D'Ortenzio RM
AUID- ORCID: 0000-0001-9228-9523
AD  - University of Toronto (R.M.D., P.O.C., L.L., A.F., R.I.A.), Toronto, Ontario,
      Canada.
FAU - Hojjat, S P
AU  - Hojjat SP
AUID- ORCID: 0000-0003-0188-1578
AD  - Medical Imaging (S.P.H., R.V., R.I.A.), Sunnybrook Health Sciences Centre,
      Toronto, Ontario, Canada r.dortenzio@mail.utoronto.ca.
FAU - Vitorino, R
AU  - Vitorino R
AUID- ORCID: 0000-0001-6416-6278
AD  - Medical Imaging (S.P.H., R.V., R.I.A.), Sunnybrook Health Sciences Centre,
      Toronto, Ontario, Canada.
FAU - Cantrell, C G
AU  - Cantrell CG
AUID- ORCID: 0000-0003-0559-8681
AD  - Departments of Biomedical Engineering (C.G.C., T.J.C.).
FAU - Lee, L
AU  - Lee L
AUID- ORCID: 0000-0001-7322-9672
AD  - Neurology (L.L.).
AD  - University of Toronto (R.M.D., P.O.C., L.L., A.F., R.I.A.), Toronto, Ontario,
      Canada.
FAU - Feinstein, A
AU  - Feinstein A
AUID- ORCID: 0000-0002-0132-0909
AD  - From the Departments of Psychiatry (A.F.).
AD  - University of Toronto (R.M.D., P.O.C., L.L., A.F., R.I.A.), Toronto, Ontario,
      Canada.
FAU - O'Connor, P
AU  - O'Connor P
AUID- ORCID: 0000-0002-5632-8385
AD  - University of Toronto (R.M.D., P.O.C., L.L., A.F., R.I.A.), Toronto, Ontario,
      Canada.
FAU - Carroll, T J
AU  - Carroll TJ
AUID- ORCID: 0000-0002-5149-8377
AD  - Departments of Biomedical Engineering (C.G.C., T.J.C.).
AD  - Radiology (T.J.C.), Northwestern University, Chicago, Illinois.
FAU - Aviv, R I
AU  - Aviv RI
AUID- ORCID: 0000-0003-0259-970X
AD  - Medical Imaging (S.P.H., R.V., R.I.A.), Sunnybrook Health Sciences Centre,
      Toronto, Ontario, Canada.
AD  - University of Toronto (R.M.D., P.O.C., L.L., A.F., R.I.A.), Toronto, Ontario,
      Canada.
LA  - eng
GR  - R01 NS049395/NS/NINDS NIH HHS/United States
GR  - R21 EB017928/EB/NIBIB NIH HHS/United States
GR  - CIHR/Canada
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, N.I.H., Extramural
DEP - 20160929
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
RN  - 0 (Spin Labels)
SB  - IM
MH  - Adult
MH  - Brain/*blood supply/diagnostic imaging/physiopathology
MH  - Cerebrovascular Circulation/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*diagnostic imaging/*physiopathology
MH  - Prospective Studies
MH  - Spin Labels
PMC - PMC5161663
MID - NIHMS805794
COIS- Statement of Conflict of Interest The authors have no conflict of interest to
      declare regarding this study.
EDAT- 2016/10/01 06:00
MHDA- 2017/09/28 06:00
CRDT- 2016/10/01 06:00
PHST- 2016/05/14 00:00 [received]
PHST- 2016/06/23 00:00 [accepted]
PHST- 2016/10/01 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2016/10/01 06:00 [entrez]
AID - ajnr.A4939 [pii]
AID - 10.3174/ajnr.A4939 [doi]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2016 Dec;37(12):2265-2272. doi: 10.3174/ajnr.A4939. Epub
      2016 Sep 29.