PMID- 27662299
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20180604
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 55
IP  - 1
DP  - 2017
TI  - White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in
      Non-Demented Older Individuals with Abnormal Amyloid-beta.
PG  - 333-342
AB  - Cerebral small vessel disease (cSVD) and amyloid-beta (Abeta) deposition often
      co-exist in (prodromal) dementia, and both types of pathology have been
      associated with neurodegeneration. We examined whether cSVD and Abeta have
      independent or interactive effects on hippocampal volume (HV) in a memory clinic 
      population. We included 87 individuals with clinical diagnoses of Alzheimer's
      disease (AD) (n = 24), mild cognitive impairment (MCI) (n = 26), and subjective
      cognitive complaints (SCC) (n = 37). cSVD magnetic resonance imaging markers
      included white matter hyperintensity (WMH) volume, lacunar infarct presence, and 
      microbleed presence. Abeta pathology was assessed as cerebrospinal fluid-derived 
      Abeta1 - 42 levels and dichotomized into normal or abnormal, and HV was
      determined by manual volumetric measurements. A linear hierarchical regression
      approach was applied for the detection of additive or interaction effects between
      cSVD and Abeta on HV in the total participant group (n = 87) and in the
      non-demented group (including SCC and MCI individuals only, n = 63). The results 
      revealed that abnormal Abeta and lacunar infarct presence were independently
      associated with lower HV in the non-demented individuals. Interestingly, Abeta
      and WMH pathology interacted in the non-demented individuals, such that WMH had a
      negative effect on HV in individuals with abnormal CSF Abeta42 levels, but not in
      individuals with normal CSF Abeta42 levels. These associations were not present
      when individuals with AD were included in the analyses. Our observations suggest 
      that relatively early on in the disease process older individuals with abnormal
      Abeta levels are at an increased risk of accelerated disease progression when
      concomitant cSVD is present.
FAU - Freeze, Whitney M
AU  - Freeze WM
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
AD  - Department of Radiology & Nuclear Medicine, Maastricht University Medical Center,
      School for Mental Health and Neuroscience, Maastricht, The Netherlands.
FAU - Jacobs, Heidi I L
AU  - Jacobs HI
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
FAU - Gronenschild, Ed H
AU  - Gronenschild EH
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
FAU - Jansen, Jacobus F A
AU  - Jansen JF
AD  - Department of Radiology & Nuclear Medicine, Maastricht University Medical Center,
      School for Mental Health and Neuroscience, Maastricht, The Netherlands.
FAU - Burgmans, Saartje
AU  - Burgmans S
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
FAU - Aalten, Pauline
AU  - Aalten P
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
FAU - Clerx, Lies
AU  - Clerx L
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
FAU - Vos, Stephanie J
AU  - Vos SJ
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
FAU - van Buchem, Mark A
AU  - van Buchem MA
AD  - Department of Radiology, Leiden University Medical Center, Leiden, The
      Netherlands.
FAU - Barkhof, Frederik
AU  - Barkhof F
AD  - Department of Radiology & Nuclear Medicine, VU University Medical Center,
      Amsterdam, The Netherlands.
AD  - Institutes of Neurology and Healthcare Engineering, University College Lodon,
      London, UK.
FAU - van der Flier, Wiesje M
AU  - van der Flier WM
AD  - Department of Neurology, VU University Medical Center, Amsterdam, The
      Netherlands.
FAU - Verbeek, Marcel M
AU  - Verbeek MM
AD  - Departments of Neurology and Laboratory Medicine, Radboud University Medical
      Center Nijmegen, Donders Institute for Brain, Cognition and Behaviour, and
      Radboud Alzheimer Center, Nijmegen, The Netherlands.
FAU - Rikkert, Marcel Olde
AU  - Rikkert MO
AD  - Department of Geriatric Medicine, Radboud University Medical Center Nijmegen,
      Donders Institute for Brain, Cognition and Behaviour, and Radboud UMC, Alzheimer 
      Center, Nijmegen, The Netherlands.
FAU - Backes, Walter H
AU  - Backes WH
AD  - Department of Radiology & Nuclear Medicine, Maastricht University Medical Center,
      School for Mental Health and Neuroscience, Maastricht, The Netherlands.
FAU - Verhey, Frans R
AU  - Verhey FR
AD  - Department of Psychiatry and Neuropsychology, Maastricht University, School for
      Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The
      Netherlands.
CN  - LeARN project
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/cerebrospinal fluid/diagnostic imaging
MH  - Amyloid beta-Peptides/*cerebrospinal fluid
MH  - Biomarkers/cerebrospinal fluid
MH  - Cerebral Hemorrhage/diagnostic imaging
MH  - Cerebral Small Vessel Diseases/cerebrospinal fluid/*diagnostic imaging
MH  - Cognition
MH  - Cognitive Dysfunction/cerebrospinal fluid/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hippocampus/*diagnostic imaging
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Organ Size
MH  - Perception
MH  - White Matter/*diagnostic imaging
OTO - NOTNLM
OT  - *Amyloid-beta
OT  - *cerebral small vessel disease
OT  - *dementia
OT  - *neurodegeneration
EDAT- 2016/09/24 06:00
MHDA- 2018/02/16 06:00
CRDT- 2016/09/24 06:00
PHST- 2016/09/24 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2016/09/24 06:00 [entrez]
AID - JAD160474 [pii]
AID - 10.3233/JAD-160474 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2017;55(1):333-342. doi: 10.3233/JAD-160474.