PMID- 27654032
OWN - NLM
STAT- MEDLINE
DCOM- 20170510
LR  - 20181113
IS  - 1476-5489 (Electronic)
IS  - 0955-9930 (Linking)
VI  - 29
IP  - 1
DP  - 2017 Jan
TI  - Erectile dysfunction in young men with type 1 diabetes.
PG  - 17-22
LID - 10.1038/ijir.2016.38 [doi]
AB  - Erectile dysfunction (ED) is a common comorbidity of diabetes mellitus, but few
      studies investigated its prevalence in type 1 diabetes. The objective of this
      study was to evaluate the prevalence and correlates of ED in young men with type 
      1 diabetes treated with different intensive insulin regimens. The study
      population included 151 type 1 diabetic men, aged 18-35 years, and 60 healthy
      age-matched controls. Ninety-four men were treated with multiple daily injections
      of insulin (MDI), and the remaining 71 with continuous subcutaneous insulin
      infusion (CSII). All participants in the study completed the International Index 
      of Erectile function (IIEF-5), and other validated multiple-choice questionnaires
      assessing quality of life, physical activity, depressive symptoms and
      diabetes-related problems. The overall prevalence of ED was higher in diabetic
      men (37%), as compared with controls (6%, P<0.001). ED prevalence rates were
      similar in both MDI (36%) and CSII (39%) groups (P=0.326); both were higher
      compared with controls (P<0.001 for both). More than half of diabetic men (58%)
      had mild ED. Compared with men without ED, diabetic men with ED showed lower
      weight, body mass index, fasting glucose, insulin dose and high-density
      lipoprotein cholesterol levels, and higher self-rating depression score (SRDS).
      In the multiple regression analysis only the SRDS (P=0.032) were independent
      predictors of IIEF-5 score in the overall diabetic men. Young men with type 1
      diabetes treated with MDI or CSII show a higher prevalence of ED, as compared
      with healthy age-matched men. Depression was associated with ED in diabetic
      population.
FAU - Maiorino, M I
AU  - Maiorino MI
AD  - Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical,
      Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, 
      Italy.
FAU - Bellastella, G
AU  - Bellastella G
AD  - Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical,
      Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, 
      Italy.
FAU - Della Volpe, E
AU  - Della Volpe E
AD  - Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical,
      Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, 
      Italy.
FAU - Casciano, O
AU  - Casciano O
AD  - Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical,
      Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, 
      Italy.
FAU - Scappaticcio, L
AU  - Scappaticcio L
AD  - Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical,
      Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, 
      Italy.
FAU - Cirillo, P
AU  - Cirillo P
AD  - Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical,
      Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, 
      Italy.
FAU - Giugliano, D
AU  - Giugliano D
AD  - Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical,
      Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, 
      Italy.
FAU - Esposito, K
AU  - Esposito K
AD  - Diabetes Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences 
      and Aging, Second University of Naples, Naples, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20160922
PL  - England
TA  - Int J Impot Res
JT  - International journal of impotence research
JID - 9007383
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Depression
MH  - Diabetes Mellitus, Type 1/*complications/*drug therapy
MH  - Erectile Dysfunction/*epidemiology/*psychology
MH  - Exercise
MH  - Humans
MH  - Insulin/administration & dosage/*therapeutic use
MH  - Insulin Infusion Systems
MH  - Italy
MH  - Longitudinal Studies
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life
MH  - Risk Factors
MH  - Self Report
MH  - Time Factors
MH  - Young Adult
EDAT- 2016/09/23 06:00
MHDA- 2017/05/11 06:00
CRDT- 2016/09/23 06:00
PHST- 2016/05/16 00:00 [received]
PHST- 2016/07/13 00:00 [revised]
PHST- 2016/07/28 00:00 [accepted]
PHST- 2016/09/23 06:00 [pubmed]
PHST- 2017/05/11 06:00 [medline]
PHST- 2016/09/23 06:00 [entrez]
AID - ijir201638 [pii]
AID - 10.1038/ijir.2016.38 [doi]
PST - ppublish
SO  - Int J Impot Res. 2017 Jan;29(1):17-22. doi: 10.1038/ijir.2016.38. Epub 2016 Sep
      22.