PMID- 27623135
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20180207
IS  - 1473-5636 (Electronic)
IS  - 0960-8931 (Linking)
VI  - 26
IP  - 6
DP  - 2016 Dec
TI  - Microsatellite instability in melanoma: a comprehensive review.
PG  - 545-550
AB  - Microsatellite instability (MSI) and mismatch repair deficiency are an emerging
      issue in oncology and molecular pathology. Besides being associated with better
      clinical outcome in colon cancer, MSI also harbors the potential to predict
      response to chemotherapy and immunotherapy. MSI was also observed in other solid 
      tumors, including endometrial cancer, ovarian cancer, and melanoma, besides colon
      cancer. Strong evidence shows that MSI is a frequent event in melanoma. However, 
      the data on MSI prevalence, pathogenesis, and clinical consequences in melanoma
      are limited. Therefore, we summarize the current knowledge on MSI in melanoma and
      outline future perspectives and clinical implications, including its role as a
      prognostic and/or a predictive factor.
FAU - Kubecek, Ondrej
AU  - Kubecek O
AD  - Department of Oncology and Radiotherapy, Charles University in Prague, Medical
      Faculty and University Hospital, Hradec Kralove, Czech Republic.
FAU - Kopecky, Jindrich
AU  - Kopecky J
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Melanoma Res
JT  - Melanoma research
JID - 9109623
SB  - IM
MH  - DNA Mismatch Repair/*immunology
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Melanoma/*immunology
MH  - Microsatellite Instability
MH  - Skin Neoplasms/*immunology
EDAT- 2016/10/26 06:00
MHDA- 2018/01/18 06:00
CRDT- 2016/09/14 06:00
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2016/09/14 06:00 [entrez]
AID - 10.1097/CMR.0000000000000298 [doi]
PST - ppublish
SO  - Melanoma Res. 2016 Dec;26(6):545-550. doi: 10.1097/CMR.0000000000000298.