PMID- 27599783
OWN - NLM
STAT- MEDLINE
DCOM- 20180314
LR  - 20180314
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 44
IP  - 2
DP  - 2017 Feb
TI  - Identification of nail features associated with psoriasis severity.
PG  - 147-153
LID - 10.1111/1346-8138.13565 [doi]
AB  - There are no detailed studies of the prevalence of nail psoriasis and clinical
      characteristics of psoriatic nail involvement, including nail features associated
      with disease severity. Therefore, we designed a study to investigate the
      prevalence and characteristics of psoriatic nail involvement in patients with
      psoriasis and determine the relationship between psoriatic nail features and
      severity of nail psoriasis and cutaneous psoriasis. The Nail Psoriasis Severity
      Index (NAPSI) was used for evaluation of the severity of nail lesions. The
      presence of nail fold psoriasis (NFP) was also assessed. The severity of
      psoriasis was evaluated by calculating the Psoriasis Area and Severity Index
      (PASI). As a result, the prevalence of nail psoriasis was 85.5%. Pitting was the 
      most common clinical feature (55.6%). The severity of nail psoriasis was not
      affected by medical parameters, although patients with localized pustular
      psoriasis tended to have more severe nail psoriasis than did those with chronic
      plaque psoriasis. When comparing the mean NAPSI and the mean PASI according to
      nail lesions, we found that subungual hyperkeratosis (SH) and NFP were
      significantly associated with the severity of both nail psoriasis and cutaneous
      psoriasis. Psoriatic nail changes were most common in the first digit.
      Conclusively, the majority of patients with psoriasis had psoriatic nail
      involvement, and Koebner's response seems to be closely related to the induction 
      of nail psoriasis. To limit progression of the disease, psoriatic patients with
      SH or NFP should be examined thoroughly because those clinical features reflect
      the levels of severity of both nail and cutaneous psoriasis.
CI  - (c) 2016 Japanese Dermatological Association.
FAU - Choi, Jee Woong
AU  - Choi JW
AD  - Department of Dermatology, Seoul National University College of Medicine, and
      Seoul National University Hospital Bundang Hospital, Seongnam, South Korea.
FAU - Kim, Bo Ri
AU  - Kim BR
AD  - Department of Dermatology, Seoul National University College of Medicine, and
      Seoul National University Hospital Bundang Hospital, Seongnam, South Korea.
FAU - Seo, Eunmi
AU  - Seo E
AD  - Department of Dermatology, Seoul National University College of Medicine, and
      Seoul National University Hospital Bundang Hospital, Seongnam, South Korea.
FAU - Youn, Sang Woong
AU  - Youn SW
AD  - Department of Dermatology, Seoul National University College of Medicine, and
      Seoul National University Hospital Bundang Hospital, Seongnam, South Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160907
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nails/*pathology
MH  - Psoriasis/*pathology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Nail Psoriasis Severity Index
OT  - Psoriasis Area and Severity Index
OT  - nail fold psoriasis
OT  - nail psoriasis
OT  - subungual hyperkeratosis
EDAT- 2016/09/08 06:00
MHDA- 2018/03/15 06:00
CRDT- 2016/09/08 06:00
PHST- 2016/03/04 00:00 [received]
PHST- 2016/07/25 00:00 [accepted]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2018/03/15 06:00 [medline]
PHST- 2016/09/08 06:00 [entrez]
AID - 10.1111/1346-8138.13565 [doi]
PST - ppublish
SO  - J Dermatol. 2017 Feb;44(2):147-153. doi: 10.1111/1346-8138.13565. Epub 2016 Sep
      7.