PMID- 27599725
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20180129
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 354
DP  - 2016 Sep 6
TI  - Atrial fibrillation and risks of cardiovascular disease, renal disease, and
      death: systematic review and meta-analysis.
PG  - i4482
LID - 10.1136/bmj.i4482 [doi]
AB  - OBJECTIVE: To quantify the association between atrial fibrillation and
      cardiovascular disease, renal disease, and death. DESIGN: Systematic review and
      meta-analysis. DATA SOURCES: Medline and Embase. ELIGIBILITY CRITERIA: Cohort
      studies examining the association between atrial fibrillation and cardiovascular 
      disease, renal disease, and death. Two reviewers independently extracted study
      characteristics and the relative risk of outcomes associated with atrial
      fibrillation: specifically, all cause mortality, cardiovascular mortality, major 
      cardiovascular events, any stroke, ischaemic stroke, haemorrhagic stroke,
      ischaemic heart disease, sudden cardiac death, congestive heart failure, chronic 
      kidney disease, and peripheral arterial disease. Estimates were pooled with
      inverse variance weighted random effects meta-analysis. RESULTS: 104 eligible
      cohort studies involving 9 686 513 participants (587 867 with atrial
      fibrillation) were identified. Atrial fibrillation was associated with an
      increased risk of all cause mortality (relative risk 1.46, 95% confidence
      interval 1.39 to 1.54), cardiovascular mortality (2.03, 1.79 to 2.30), major
      cardiovascular events (1.96, 1.53 to 2.51), stroke (2.42, 2.17 to 2.71),
      ischaemic stroke (2.33, 1.84 to 2.94), ischaemic heart disease (1.61, 1.38 to
      1.87), sudden cardiac death (1.88, 1.36 to 2.60), heart failure (4.99, 3.04 to
      8.22), chronic kidney disease (1.64, 1.41 to 1.91), and peripheral arterial
      disease (1.31, 1.19 to 1.45) but not haemorrhagic stroke (2.00, 0.67 to 5.96).
      Among the outcomes examined, the highest absolute risk increase was for heart
      failure. Associations between atrial fibrillation and included outcomes were
      broadly consistent across subgroups and in sensitivity analyses. CONCLUSIONS:
      Atrial fibrillation is associated with an increased risk of death and an
      increased risk of cardiovascular and renal disease. Interventions aimed at
      reducing outcomes beyond stroke are warranted in patients with atrial
      fibrillation.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not
      already granted under a licence) please go to
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Odutayo, Ayodele
AU  - Odutayo A
AD  - Centre for Statistics in Medicine, Nuffield Department of Orthopaedics,
      Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
      ayodele.odutayo@bnc.ox.ac.uk.
FAU - Wong, Christopher X
AU  - Wong CX
AD  - Nuffield Department of Population Health, University of Oxford, Oxford, UK.
FAU - Hsiao, Allan J
AU  - Hsiao AJ
AD  - Department of Economics, Massachusetts Institute of Technology, Cambridge, MA,
      USA.
FAU - Hopewell, Sally
AU  - Hopewell S
AD  - Centre for Statistics in Medicine, Nuffield Department of Orthopaedics,
      Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
FAU - Altman, Douglas G
AU  - Altman DG
AD  - Centre for Statistics in Medicine, Nuffield Department of Orthopaedics,
      Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
FAU - Emdin, Connor A
AU  - Emdin CA
AD  - St John's College, University of Oxford, Oxford, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20160906
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - AIM
SB  - IM
CIN - Am J Nurs. 2017 Apr;117(4):66. PMID: 28333749
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Atrial Fibrillation/complications/*mortality
MH  - Death, Sudden, Cardiac/epidemiology
MH  - Female
MH  - Heart Failure/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/mortality
MH  - Prevalence
MH  - Renal Insufficiency, Chronic/mortality
MH  - Risk Factors
MH  - Sex Distribution
MH  - Stroke/mortality
EDAT- 2016/09/08 06:00
MHDA- 2017/03/28 06:00
CRDT- 2016/09/08 06:00
PHST- 2016/09/08 06:00 [entrez]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
PST - epublish
SO  - BMJ. 2016 Sep 6;354:i4482.