PMID- 27585211
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1531-7021 (Electronic)
IS  - 1040-8738 (Linking)
VI  - 27
IP  - 6
DP  - 2016 Nov
TI  - Ocular manifestations of inflammatory bowel disease.
PG  - 552-560
AB  - PURPOSE OF REVIEW: Extraintestinal manifestations (EIMs) of inflammatory bowel
      disease (IBD) are numerous and can often involve the eye. This review highlights 
      the ocular complications associated with IBD including the critical role the
      ophthalmologist can play in the diagnosis of IBD, the pathogenesis of IBD, its
      ocular complications, and the treatment of ocular inflammation associated with
      IBD. RECENT FINDINGS: Polygenic and environmental influences, as well as gut
      microbial dysbiosis, have been implicated in the pathogenesis of IBD. IBD and its
      EIMs appear to respond well to TNFalpha-targeted biologics. SUMMARY: IBD is
      thought to be caused by polygenic and environmental influences, including a
      dysbiotic gut microbiota. It is a systemic immune-mediated disease with varying
      types of ocular manifestations that can precede, occur simultaneously, or follow 
      intestinal involvement. The diagnosis of IBD can be confused with other
      seronegative spondyloarthropathies as well as Behcet's disease. Treatment of
      IBD-associated ocular inflammation can range from corticosteroids to
      steroid-sparing immunosuppression such as azathioprine or methotrexate.
      Refractory disease can respond well to TNFalpha inhibitors.
FAU - Thomas, Akshay S
AU  - Thomas AS
AD  - Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon,
      USA.
FAU - Lin, Phoebe
AU  - Lin P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Ophthalmol
JT  - Current opinion in ophthalmology
JID - 9011108
SB  - IM
MH  - Adult
MH  - Aged
MH  - Eye Diseases/*diagnosis/*drug therapy/etiology
MH  - Female
MH  - Humans
MH  - Inflammatory Bowel Diseases/complications/*diagnosis
MH  - *Ophthalmology
MH  - *Physician's Role
EDAT- 2016/10/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/09/02 06:00
PHST- 2016/10/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/09/02 06:00 [entrez]
AID - 10.1097/ICU.0000000000000310 [doi]
PST - ppublish
SO  - Curr Opin Ophthalmol. 2016 Nov;27(6):552-560. doi: 10.1097/ICU.0000000000000310.