PMID- 27580369
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20170817
IS  - 1600-0412 (Electronic)
IS  - 0001-6349 (Linking)
VI  - 95
IP  - 11
DP  - 2016 Nov
TI  - Maternal smoking during pregnancy and risk of stillbirth: results from a
      nationwide Danish register-based cohort study.
PG  - 1305-1312
LID - 10.1111/aogs.13011 [doi]
AB  - INTRODUCTION: Maternal smoking during pregnancy has been associated with an
      increased risk of stillbirth. Only a few studies have been conducted to determine
      whether smoking affects the risk of antepartum and intrapartum stillbirth
      differently or whether smoking cessation in early pregnancy reduces the risk.
      Previous results are inconclusive. We addressed these questions in a large Danish
      population-based cohort study. MATERIAL AND METHODS: From the Danish Medical
      Birth Register, we identified 841 228 singleton births in Denmark between 1997
      and 2010 and gathered detailed information on maternal smoking during pregnancy
      and the vital status of the infant. Associations (odds ratios with 95% confidence
      intervals) between maternal smoking and risk of stillbirth overall and separately
      for antepartum and intrapartum stillbirth were analyzed using logistic regression
      models (generalized estimating equations), adjusting for potential confounders.
      RESULTS: Any smoking during pregnancy increased the risk of stillbirth, both
      overall (odds ratio 1.42, 95% confidence interval 1.30-1.55) and for antepartum
      (odds ratio 1.38, 95% confidence interval 1.25-1.53) and intrapartum (odds ratio 
      1.52, 95% confidence interval 1.18-1.96) stillbirths. Women who quit smoking at
      the beginning of the second trimester at the latest had no increased risk of
      stillbirth overall (odds ratio 1.03, 95% confidence interval 0.80-1.32).
      CONCLUSIONS: Maternal smoking during pregnancy increases the risk of stillbirth, 
      both overall and for antepartum and intrapartum stillbirth separately. Women who 
      quit smoking in the beginning of their pregnancy reduce their risk compared with 
      that of non-smokers.
CI  - (c) 2016 Nordic Federation of Societies of Obstetrics and Gynecology.
FAU - Bjornholt, Sarah M
AU  - Bjornholt SM
AD  - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen,
      Denmark.
FAU - Leite, Mimmi
AU  - Leite M
AD  - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen,
      Denmark.
FAU - Albieri, Vanna
AU  - Albieri V
AD  - Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center,
      Copenhagen, Denmark.
FAU - Kjaer, Susanne K
AU  - Kjaer SK
AD  - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen,
      Denmark.
AD  - Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen,
      Denmark.
FAU - Jensen, Allan
AU  - Jensen A
AD  - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen,
      Denmark. allan@cancer.dk.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - *Maternal Behavior
MH  - Pregnancy
MH  - Registries
MH  - Risk Factors
MH  - Smoking/*adverse effects/epidemiology
MH  - Smoking Cessation/statistics & numerical data
MH  - Stillbirth/*epidemiology
OTO - NOTNLM
OT  - Denmark
OT  - Maternal smoking
OT  - cohort study
OT  - epidemiology
OT  - pregnancy
OT  - stillbirth
EDAT- 2016/10/21 06:00
MHDA- 2017/02/18 06:00
CRDT- 2016/09/01 06:00
PHST- 2016/04/08 00:00 [received]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
PHST- 2016/09/01 06:00 [entrez]
AID - 10.1111/aogs.13011 [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2016 Nov;95(11):1305-1312. doi: 10.1111/aogs.13011.