PMID- 27559051
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20180201
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 197
IP  - 7
DP  - 2016 Oct 1
TI  - Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for
      Systemic Lupus Erythematosus Development.
PG  - 2618-26
LID - 10.4049/jimmunol.1401129 [doi]
AB  - Autoimmune diseases are characterized by pathogenic immune responses to
      self-antigens. In systemic lupus erythematosus (SLE), many self-antigens are
      found in apoptotic cells (ACs), and defects in removal of ACs from the body are
      linked to a risk for developing SLE. This includes pathological memory that gives
      rise to disease flares. In this study, we investigated how memory to AC-derived
      self-antigens develops and the contribution of self-memory to the development of 
      lupus-related pathology. Multiple injections of ACs without adjuvant into
      wild-type mice induce a transient primary autoimmune response without apparent
      anti-nuclear Ab reactivity or kidney pathology. Interestingly, as the transient
      Ab response reached baseline, a single boost injection fully recalled the immune 
      response to ACs, and this memory response was furthermore transferable into naive
      mice. Additionally, the memory response contains elements of pathogenicity,
      accompanied by selective memory to selective Ags. Thus, we provide evidence for a
      selective self-memory that underlies progression of the response to self-antigens
      with implications for SLE development therapy.
CI  - Copyright (c) 2016 by The American Association of Immunologists, Inc.
FAU - Duhlin, Amanda
AU  - Duhlin A
AUID- ORCID: 0000-0003-1504-4789
AD  - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77
      Stockholm, Sweden;
FAU - Chen, Yunying
AU  - Chen Y
AD  - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77
      Stockholm, Sweden;
FAU - Wermeling, Fredrik
AU  - Wermeling F
AUID- ORCID: 0000-0001-9633-677X
AD  - Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden; and.
FAU - Sedimbi, Saikiran K
AU  - Sedimbi SK
AD  - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77
      Stockholm, Sweden;
FAU - Lindh, Emma
AU  - Lindh E
AD  - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77
      Stockholm, Sweden;
FAU - Shinde, Rahul
AU  - Shinde R
AUID- ORCID: 0000-0001-8767-5032
AD  - Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 
      2M9, Canada.
FAU - Halaby, Marie Jo
AU  - Halaby MJ
AD  - Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 
      2M9, Canada.
FAU - Kaiser, Ylva
AU  - Kaiser Y
AD  - Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden; and.
FAU - Winqvist, Ola
AU  - Winqvist O
AD  - Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden; and.
FAU - McGaha, Tracy L
AU  - McGaha TL
AD  - Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 
      2M9, Canada.
FAU - Karlsson, Mikael C I
AU  - Karlsson MC
AD  - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77
      Stockholm, Sweden; mikael.karlsson@ki.se.
LA  - eng
GR  - R01 AR067763/AR/NIAMS NIH HHS/United States
GR  - R01 CA190449/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160824
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
SB  - AIM
SB  - IM
CIN - Nat Rev Rheumatol. 2016 Oct;12(10):559. PMID: 27627865
MH  - Animals
MH  - Apoptosis/*immunology
MH  - Autoantibodies/*immunology
MH  - Autoantigens/*immunology
MH  - Immunologic Memory/*immunology
MH  - Lupus Erythematosus, Systemic/*immunology/therapy
MH  - Mice
MH  - Mice, Inbred C57BL
PMC - PMC5026029
EDAT- 2016/08/26 06:00
MHDA- 2017/10/03 06:00
CRDT- 2016/08/26 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2016/07/27 00:00 [accepted]
PHST- 2016/08/26 06:00 [entrez]
PHST- 2016/08/26 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
AID - jimmunol.1401129 [pii]
AID - 10.4049/jimmunol.1401129 [doi]
PST - ppublish
SO  - J Immunol. 2016 Oct 1;197(7):2618-26. doi: 10.4049/jimmunol.1401129. Epub 2016
      Aug 24.