PMID- 27548068
OWN - NLM
STAT- MEDLINE
DCOM- 20171229
LR  - 20180426
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 31
IP  - 11
DP  - 2016 Nov
TI  - Subthalamic synchronized oscillatory activity correlates with motor impairment in
      patients with Parkinson's disease.
PG  - 1748-1751
LID - 10.1002/mds.26759 [doi]
AB  - OBJECTIVE: Beta band oscillations in the subthalamic nucleus (STN) have been
      proposed as a pathophysiological signature in patients with Parkinson's disease
      (PD). The aim of this study was to investigate the potential association between 
      oscillatory activity in the STN and symptom severity in PD. METHODS: Subthalamic 
      local field potentials were recorded from 63 PD patients in a dopaminergic OFF
      state. Power-spectra were analyzed for the frequency range from 5 to 95 Hz and
      correlated with individual UPDRS-III motor scores in the OFF state. RESULTS: A
      correlation between total UPDRS-III scores and 8 to 35 Hz activity was revealed
      across all patients (rho = 0.44, P < .0001). When correlating each frequency bin,
      a narrow range from 10 to 15 Hz remained significant for the correlation (false
      discovery rate corrected P < .05). CONCLUSION: Our results show a correlation
      between local STN 8 to 35 Hz power and impairment in PD, further supporting the
      role of subthalamic oscillatory activity as a potential biomarker for PD.
CI  - (c) 2016 International Parkinson and Movement Disorder Society.
FAU - Neumann, Wolf-Julian
AU  - Neumann WJ
AD  - Department of Neurology, Campus Virchow Klinikum, Charite-University Medicine
      Berlin, Berlin, Germany.
FAU - Degen, Katharina
AU  - Degen K
AD  - Department of Neurology, Campus Virchow Klinikum, Charite-University Medicine
      Berlin, Berlin, Germany.
FAU - Schneider, Gerd-Helge
AU  - Schneider GH
AD  - Department of Neurosurgery, Campus Virchow Klinikum, Charite-University Medicine 
      Berlin, Berlin, Germany.
FAU - Brucke, Christof
AU  - Brucke C
AD  - Department of Neurology, Campus Virchow Klinikum, Charite-University Medicine
      Berlin, Berlin, Germany.
FAU - Huebl, Julius
AU  - Huebl J
AD  - Department of Neurology, Campus Virchow Klinikum, Charite-University Medicine
      Berlin, Berlin, Germany.
FAU - Brown, Peter
AU  - Brown P
AD  - Nuffield Department of Clinical Neurosciences and Medical Research Council Brain 
      Network Dynamics Unit, University of Oxford, Oxford, UK.
FAU - Kuhn, Andrea A
AU  - Kuhn AA
AD  - Department of Neurology, Campus Virchow Klinikum, Charite-University Medicine
      Berlin, Berlin, Germany.
AD  - Berlin School of Mind and Brain, Charite-University Medicine Berlin, Berlin,
      Germany.
AD  - NeuroCure, Charite-University Medicine Berlin, Berlin, Germany.
AD  - Deutsches Zentrum fur Neurodegenerative Erkrankungen (DZNE), Berlin, Germany.
LA  - eng
GR  - MC_UU_12024/1/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160822
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Biomarkers)
SB  - IM
CIN - Mov Disord. 2017 Jan;32(1):174-175. PMID: 27859589
CIN - Mov Disord. 2017 Jan;32(1):175-176. PMID: 27859569
MH  - Beta Rhythm/*physiology
MH  - Biomarkers
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*physiopathology
MH  - Severity of Illness Index
MH  - Subthalamic Nucleus/*physiopathology
PMC - PMC5120686
MID - EMS70482
OTO - NOTNLM
OT  - *basal ganglia
OT  - *beta oscillations
OT  - *deep brain stimulation
OT  - *local field potentials
OT  - *subthalamic nucleus
COIS- Relevant conflicts of interests/financial disclosures: Nothing to report.
EDAT- 2016/08/23 06:00
MHDA- 2017/12/30 06:00
CRDT- 2016/08/23 06:00
PHST- 2016/05/06 00:00 [received]
PHST- 2016/07/26 00:00 [revised]
PHST- 2016/07/31 00:00 [accepted]
PHST- 2016/08/23 06:00 [pubmed]
PHST- 2017/12/30 06:00 [medline]
PHST- 2016/08/23 06:00 [entrez]
AID - 10.1002/mds.26759 [doi]
PST - ppublish
SO  - Mov Disord. 2016 Nov;31(11):1748-1751. doi: 10.1002/mds.26759. Epub 2016 Aug 22.