PMID- 27488261
OWN - NLM
STAT- MEDLINE
DCOM- 20171109
LR  - 20180517
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 19
IP  - 2
DP  - 2017 Feb
TI  - Relaxin serum levels in acute heart failure are associated with pulmonary
      hypertension and right heart overload.
PG  - 218-225
LID - 10.1002/ejhf.611 [doi]
AB  - AIMS: Despite the promising results of serelaxin as a new potential acute heart
      failure (HF) therapy, its clinical use preceded the understanding of the
      endogenous relaxin system in HF. We aimed to evaluate relaxin circulating levels 
      in a population of acute HF and their association with clinical and
      echocardiographic parameters. METHODS AND RESULTS: We included 117 patients from 
      a registry of acute HF. Admission serum relaxin was measured using an
      enzyme-linked immunosorbent assay (ELISA) kit. Clinical, analytical, and
      echocardiographic parameters were compared between patients with relaxin levels
      above and below the median. Median age was 82 years [interquartile range (IQR)
      72-87], 41% of the patients were male, and 63% had systolic dysfunction. Median
      serum relaxin was 31.4 pg/mL (IQR 0.6-89.8). Patients with relaxin levels above
      the median had more peripheral oedema (89.8% vs. 68.4%, P = 0.004) and a
      significantly higher sodium retention score (mean 4.8 +/- 1.5 vs. 3.6 +/- 2.0, P 
      < 0.001). These patients also had significantly higher systolic pulmonary
      arterial pressure [median 47.0 (IQR 36.0-61.0) vs. 34.5 (IQR 25.0-51.0) mmHg, P =
      0.002], higher prevalence of right ventricular (RV) systolic dysfunction (28.1%
      vs. 10.3%, P = 0.02), RV dilation (31.0% vs. 5.3%, P < 0.001), and right atrial
      dilation (66.1% vs. 36.5%, P = 0.002), and less inferior vena cava diameter
      variability (40% vs. 60%, P = 0.009). No differences were noted regarding
      admission blood pressure, left chamber dimensions, or LV function. CONCLUSION: In
      our population of acute HF patients, admission relaxin serum levels were
      associated with clinical and echocardiographic markers of pulmonary hypertension,
      RV dysfunction, and overload, suggesting a role for circulating relaxin as a
      biomarker in this setting.
CI  - (c) 2016 The Authors. European Journal of Heart Failure (c) 2016 European Society
      of Cardiology.
FAU - Pintalhao, Mariana
AU  - Pintalhao M
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine,
      University of Porto, Portugal.
AD  - Internal Medicine Department, Sao Joao Hospital Centre, Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
FAU - Castro-Chaves, Paulo
AU  - Castro-Chaves P
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine,
      University of Porto, Portugal.
AD  - Internal Medicine Department, Sao Joao Hospital Centre, Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
FAU - Vasques-Novoa, Francisco
AU  - Vasques-Novoa F
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine,
      University of Porto, Portugal.
AD  - Internal Medicine Department, Sao Joao Hospital Centre, Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
FAU - Goncalves, Francisco
AU  - Goncalves F
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine,
      University of Porto, Portugal.
FAU - Mendonca, Luis
AU  - Mendonca L
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine,
      University of Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
FAU - Fontes-Carvalho, Ricardo
AU  - Fontes-Carvalho R
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine,
      University of Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
AD  - Cardiology Department, Gaia Hospital Centre, Gaia, Portugal.
FAU - Lourenco, Patricia
AU  - Lourenco P
AD  - Internal Medicine Department, Sao Joao Hospital Centre, Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
FAU - Almeida, Pedro
AU  - Almeida P
AD  - Cardiology Department, Sao Joao Hospital Centre, Porto, Portugal.
FAU - Leite-Moreira, Adelino
AU  - Leite-Moreira A
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine,
      University of Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
AD  - Cardiothoracic Surgery Department, Sao Joao Hospital Centre, Porto, Portugal.
FAU - Bettencourt, Paulo
AU  - Bettencourt P
AD  - Internal Medicine Department, Sao Joao Hospital Centre, Porto, Portugal.
AD  - Cardiovascular Research Centre, Portugal.
AD  - Department of Medicine, Faculty of Medicine, University of Porto, Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160804
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (RLN1 protein, human)
RN  - 0 (RLN2 protein, human)
RN  - 0 (RLN3 protein, human)
RN  - 9002-69-1 (Relaxin)
SB  - IM
CIN - Eur J Heart Fail. 2017 Jul;19(7):958-960. PMID: 28244195
CIN - Eur J Heart Fail. 2017 Jul;19(7):961. PMID: 28474436
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - Echocardiography
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Failure/*blood/complications
MH  - Humans
MH  - Hypertension, Pulmonary/*blood/complications
MH  - Male
MH  - *Registries
MH  - Relaxin/*blood
MH  - Ventricular Dysfunction, Right/*blood/complications
OTO - NOTNLM
OT  - *Acute heart failure
OT  - *Circulating biomarker
OT  - *Pulmonary hypertension
OT  - *Relaxin
OT  - *Right ventricular dysfunction
EDAT- 2016/08/05 06:00
MHDA- 2017/11/10 06:00
CRDT- 2016/08/05 06:00
PHST- 2016/02/13 00:00 [received]
PHST- 2016/05/24 00:00 [revised]
PHST- 2016/06/10 00:00 [accepted]
PHST- 2016/08/05 06:00 [pubmed]
PHST- 2017/11/10 06:00 [medline]
PHST- 2016/08/05 06:00 [entrez]
AID - 10.1002/ejhf.611 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2017 Feb;19(2):218-225. doi: 10.1002/ejhf.611. Epub 2016 Aug 4.