PMID- 27424042
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20171217
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 213
IP  - 2
DP  - 2017 Feb
TI  - Predictors of 5-year local, regional, and distant recurrent events in a
      population-based cohort of breast cancer patients.
PG  - 418-425
LID - S0002-9610(16)30290-2 [pii]
LID - 10.1016/j.amjsurg.2016.03.016 [doi]
AB  - BACKGROUND: The study purpose was to identify tumor and surgeon predictors of
      local recurrence (LR), regional recurrence (RR), and distant metastasis (DM)
      after breast cancer (BC) surgery in a population-based cohort. METHODS:
      Consecutive BC surgical cases from 12 hospitals in South Central Ontario between 
      May 2006 and October 2006 were included. Data collected on chart review included 
      patient and tumor factors, surgery type, adjuvant treatment, surgeon specialty,
      surgeon case volume, and practice type. Univariate and multivariable survival
      analyses were performed. RESULTS: Median follow-up was 5.5 years for 402 patients
      (97% of sample). LR, RR, and DM occurred in 18 (4.5%), 10 (2.5%), and 47 (12%)
      patients, respectively. Significant predictors of BC recurrence (LR or RR or DM) 
      were tumor size and grade, nodal status, and lymphovascular invasion on
      multivariable analysis. CONCLUSION: Tumor factors such as size, grade,
      lymphovascular invasion, and nodal status predicted BC recurrence, while practice
      type, surgeon specialty, and case volume did not.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Fung, Filgen
AU  - Fung F
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada.
FAU - Cornacchi, Sylvie D
AU  - Cornacchi SD
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada.
FAU - Vanniyasingam, Thuva
AU  - Vanniyasingam T
AD  - Department of Clinical Epidemiology and Biostatistics, McMaster University and
      Biostatistics Unit, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
FAU - Dao, Dyda
AU  - Dao D
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada.
FAU - Thabane, Lehana
AU  - Thabane L
AD  - Department of Clinical Epidemiology and Biostatistics, McMaster University and
      Biostatistics Unit, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
FAU - Simunovic, Marko
AU  - Simunovic M
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada; Department of Surgical
      Oncology, Hamilton Health Sciences, Juravinski Hospital and Cancer Centre, 699
      Concession Street, Hamilton, Ontario, L8V 5C2, Canada.
FAU - Hodgson, Nicole
AU  - Hodgson N
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada; Department of Surgical
      Oncology, Hamilton Health Sciences, Juravinski Hospital and Cancer Centre, 699
      Concession Street, Hamilton, Ontario, L8V 5C2, Canada.
FAU - O'Brien, Mary Ann
AU  - O'Brien MA
AD  - Department of Family and Community Medicine, University of Toronto, Toronto,
      Ontario, Canada.
FAU - Reid, Susan
AU  - Reid S
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada; Department of Surgical
      Oncology, Hamilton Health Sciences, Juravinski Hospital and Cancer Centre, 699
      Concession Street, Hamilton, Ontario, L8V 5C2, Canada.
FAU - Heller, Barbara
AU  - Heller B
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada; Department of Surgical
      Oncology, Hamilton Health Sciences, Juravinski Hospital and Cancer Centre, 699
      Concession Street, Hamilton, Ontario, L8V 5C2, Canada.
FAU - Lovrics, Peter J
AU  - Lovrics PJ
AD  - Department of Surgery, McMaster University, St. Joseph's Healthcare Hamilton, 50 
      Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada; Department of Surgical
      Oncology, Hamilton Health Sciences, Juravinski Hospital and Cancer Centre, 699
      Concession Street, Hamilton, Ontario, L8V 5C2, Canada. Electronic address:
      lovricsp@mcmaster.ca.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160614
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - AIM
SB  - IM
MH  - Breast Neoplasms/*pathology/therapy
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Lymph Nodes/pathology
MH  - Mastectomy/statistics & numerical data
MH  - Mastectomy, Segmental/statistics & numerical data
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Invasiveness
MH  - *Neoplasm Metastasis
MH  - Neoplasm Recurrence, Local/*epidemiology
MH  - Ontario/epidemiology
MH  - Professional Practice Location/statistics & numerical data
MH  - Specialties, Surgical/statistics & numerical data
OTO - NOTNLM
OT  - *Breast cancer-specific mortality
OT  - *Breast conserving surgery
OT  - *Mastectomy
OT  - *Surgeon specialty
OT  - *Surgeon volume
EDAT- 2016/07/18 06:00
MHDA- 2017/04/18 06:00
CRDT- 2016/07/18 06:00
PHST- 2016/01/08 00:00 [received]
PHST- 2016/03/02 00:00 [revised]
PHST- 2016/03/09 00:00 [accepted]
PHST- 2016/07/18 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
PHST- 2016/07/18 06:00 [entrez]
AID - S0002-9610(16)30290-2 [pii]
AID - 10.1016/j.amjsurg.2016.03.016 [doi]
PST - ppublish
SO  - Am J Surg. 2017 Feb;213(2):418-425. doi: 10.1016/j.amjsurg.2016.03.016. Epub 2016
      Jun 14.