PMID- 27417004
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20170922
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 68
IP  - 3
DP  - 2016 Jul 19
TI  - Heart Failure After Myocardial Infarction Is Associated With Increased Risk of
      Cancer.
PG  - 265-271
LID - S0735-1097(16)33130-8 [pii]
LID - 10.1016/j.jacc.2016.04.053 [doi]
AB  - BACKGROUND: Heart failure (HF) is associated with excess morbidity and mortality 
      for which noncardiac causes are increasingly recognized. The authors previously
      described an increased risk of cancer among HF patients compared with community
      controls. OBJECTIVES: This study examined whether HF was associated with an
      increased risk of subsequent cancer among a homogenous population of first
      myocardial infarction (MI) survivors. METHODS: A prospective cohort study was
      conducted among Olmsted County, Minnesota, residents with incident MI from 2002
      to 2010. Patients with prior cancer or HF diagnoses were excluded. RESULTS: A
      total of 1,081 participants (mean age 64 +/- 15 years; 60% male) were followed
      for 5,327 person-years (mean 4.9 +/- 3.0 years). A total of 228 patients
      developed HF, and 98 patients developed cancer (excluding nonmelanoma skin
      cancer). Incidence density rates for cancer diagnosis (per 1,000 person-years)
      were 33.7 for patients with HF and 15.6 for patients without HF (p = 0.002). The 
      hazard ratio (HR) for cancer associated with HF was 2.16 (95% confidence interval
      [CI]: 1.39 to 3.35); adjusted for age, sex, and Charlson comorbidity index; HR:
      1.71 (95% CI: 1.07 to 2.73). The HRs for mortality associated with cancer were
      4.90 (95% CI: 3.10 to 7.74) for HF-free and 3.91 (95% CI: 1.88 to 8.12) for HF
      patients (p for interaction = 0.76). CONCLUSIONS: Patients who develop HF after
      MI have an increased risk of cancer. This finding extends our previous report of 
      an elevated cancer risk after HF compared with controls, and calls for a better
      understanding of shared risk factors and underlying mechanisms.
CI  - Copyright (c) 2016 American College of Cardiology Foundation. Published by
      Elsevier Inc. All rights reserved.
FAU - Hasin, Tal
AU  - Hasin T
AD  - Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel.
FAU - Gerber, Yariv
AU  - Gerber Y
AD  - Department of Epidemiology and Preventive Medicine, School of Public Health,
      Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of
      Health Sciences Research and Division of Cardiovascular Diseases, Mayo Clinic,
      Rochester, Minnesota.
FAU - Weston, Susan A
AU  - Weston SA
AD  - Department of Health Sciences Research and Division of Cardiovascular Diseases,
      Mayo Clinic, Rochester, Minnesota.
FAU - Jiang, Ruoxiang
AU  - Jiang R
AD  - Department of Health Sciences Research and Division of Cardiovascular Diseases,
      Mayo Clinic, Rochester, Minnesota.
FAU - Killian, Jill M
AU  - Killian JM
AD  - Department of Health Sciences Research and Division of Cardiovascular Diseases,
      Mayo Clinic, Rochester, Minnesota.
FAU - Manemann, Sheila M
AU  - Manemann SM
AD  - Department of Health Sciences Research and Division of Cardiovascular Diseases,
      Mayo Clinic, Rochester, Minnesota.
FAU - Cerhan, James R
AU  - Cerhan JR
AD  - Department of Health Sciences Research and Division of Cardiovascular Diseases,
      Mayo Clinic, Rochester, Minnesota.
FAU - Roger, Veronique L
AU  - Roger VL
AD  - Department of Health Sciences Research and Division of Cardiovascular Diseases,
      Mayo Clinic, Rochester, Minnesota. Electronic address: roger.veronique@mayo.edu.
LA  - eng
GR  - R01 AG034676/AG/NIA NIH HHS/United States
GR  - R01 HL059205/HL/NHLBI NIH HHS/United States
GR  - R01 HL072435/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - AIM
SB  - IM
CIN - J Am Coll Cardiol. 2016 Jul 19;68(3):272-273. PMID: 27417005
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*complications/epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Minnesota/epidemiology
MH  - Myocardial Infarction/epidemiology/*etiology
MH  - Neoplasms/epidemiology/*etiology
MH  - Prospective Studies
MH  - *Risk Assessment
MH  - Risk Factors
MH  - Survival Rate/trends
MH  - Time Factors
PMC - PMC4947209
MID - NIHMS789185
OTO - NOTNLM
OT  - epidemiology
OT  - follow-up studies
OT  - risk
EDAT- 2016/07/16 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/07/16 06:00
PHST- 2016/01/29 00:00 [received]
PHST- 2016/04/10 00:00 [revised]
PHST- 2016/04/12 00:00 [accepted]
PHST- 2016/07/16 06:00 [entrez]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - S0735-1097(16)33130-8 [pii]
AID - 10.1016/j.jacc.2016.04.053 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2016 Jul 19;68(3):265-271. doi: 10.1016/j.jacc.2016.04.053.