PMID- 27357364
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20170512
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 135
IP  - 5
DP  - 2017 May
TI  - Need for symptomatic management in advanced multiple sclerosis.
PG  - 529-532
LID - 10.1111/ane.12631 [doi]
AB  - OBJECTIVE: A majority of patients with advanced multiple sclerosis (MS) need
      symptomatic treatment. Many MS-related symptoms may not be recognized and thus
      are not treated. We conducted a study to estimate the prevalence of inadequate
      symptomatic treatment of patients with advanced MS. METHODS: Patients with
      advanced MS admitted to a specialist MS rehabilitation clinic were included in
      this study. Severity was assessed using the Expanded Disability Status Scale
      (EDSS). The information we collected included age of onset, initial course, time 
      to sustained disability, pharmacological treatment, degree of spasticity, pain
      and bladder dysfunction, and unmet needs of symptomatic treatment. RESULTS: In
      total, we assessed demographic and clinical characteristics in 129 patients with 
      a mean age of 56 years and a median EDSS of 7.5. The proportion with inadequate
      symptom treatment was regarding spasticity 46%, pain 28%, and bladder dysfunction
      23%. DISCUSSION: This study showed that a large proportion of patients with
      advanced MS had lack of symptomatic treatment. These patients probably underuse
      neurological specialist services. Better symptomatic treatment could contribute
      to improving quality of life of people with MS.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Ronning, O M
AU  - Ronning OM
AD  - Department of Neurology, Akershus University Hospital, Lorenskog, Norway.
AD  - Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
FAU - Tornes, K D
AU  - Tornes KD
AD  - Eiksasen Multiple Sclerosis Rehabilitation Centre, Baerum, Norway.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160629
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - *Disease Management
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/*epidemiology/*therapy
MH  - Muscle Spasticity/diagnosis/*epidemiology/*therapy
MH  - Norway/epidemiology
MH  - Pain/diagnosis/epidemiology
MH  - Prevalence
MH  - Quality of Life
MH  - *Severity of Illness Index
OTO - NOTNLM
OT  - *multiple sclerosis
OT  - *pain
OT  - *spasticity
OT  - *symptomatic treatment
EDAT- 2016/07/01 06:00
MHDA- 2017/05/13 06:00
CRDT- 2016/07/01 06:00
PHST- 2016/06/09 00:00 [accepted]
PHST- 2016/07/01 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
PHST- 2016/07/01 06:00 [entrez]
AID - 10.1111/ane.12631 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2017 May;135(5):529-532. doi: 10.1111/ane.12631. Epub 2016 Jun
      29.