PMID- 27340748
DCOM- 20170719
LR  - 20180913
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 40
IP  - 9
DP  - 2016 Sep
TI  - Primary Endometrial Marginal Zone Lymphoma (MALT Lymphoma): A Unique
      Clinicopathologic Entity.
PG  - 1217-23
LID - 10.1097/PAS.0000000000000683 [doi]
AB  - Primary lymphoma of the endometrium is exceptionally rare. Several cases of
      distinctly nodular lymphoid proliferations confined to the endometrium have
      previously been described and reported as lymphomas of mucosa-associated lymphoid
      tissue (MALT). We report the largest series (n=8) of these lymphomas, further
      defining their morphologic, immunohistochemical, and molecular spectrum. Patients
      ranged in age from 50 to 87 (median, 62) years. None had a prior history of
      lymphoma, and lesions were incidental in all but 1 in which a polyp was noted on 
      macroscopic examination. Nodules ranged from small, round, and uniform with
      minimal architectural effacement to large, expansile, and coalescing with foci of
      diffuse growth. In the majority, the nodules were confined to the endometrium;
      however, 2 cases showed myometrial involvement, 1 of which also had extensive
      extrauterine disease. The nodules comprised monomorphic populations of mature
      CD20 B lymphocytes with pale scant cytoplasm, CD43, BCL2, and IgM coexpression,
      and absence of CD10, CD23, and IgD expression. The nodules were associated with
      CD21/CD23 follicular dendritic meshworks. Clonality was detected in 6 lesions, in
      4 by polymerase chain reaction for clonal IGH rearrangement and in 3 by in situ
      hybridization for immunoglobulin light chains. All were negative for IGH and
      MALT1 rearrangements by fluorescence in situ hybridization. None of the patients 
      received additional therapy after resection, and most (7/8) are alive with no
      evidence of disease at last follow-up (mean 4.2 y), whereas the remaining patient
      is alive with stable disease. These findings demonstrate the unique clinical and 
      pathologic features that characterize primary MALT lymphoma of the endometrium.
FAU - Bennett, Jennifer A
AU  - Bennett JA
AD  - *Department of Pathology, Massachusetts General Hospital daggerDepartment of
      Pathology, The Brigham and Women's Hospital, Harvard Medical School Boston,
      Boston, MA.
FAU - Oliva, Esther
AU  - Oliva E
FAU - Nardi, Valentina
AU  - Nardi V
FAU - Lindeman, Neal
AU  - Lindeman N
FAU - Ferry, Judith A
AU  - Ferry JA
FAU - Louissaint, Abner Jr
AU  - Louissaint A Jr
LA  - eng
GR  - UL1 TR001102/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/analysis
MH  - Endometrial Neoplasms/*pathology
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunoglobulin Heavy Chains
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*pathology
MH  - Middle Aged
EDAT- 2016/06/25 06:00
MHDA- 2017/07/20 06:00
CRDT- 2016/06/25 06:00
PHST- 2016/06/25 06:00 [entrez]
PHST- 2016/06/25 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
AID - 10.1097/PAS.0000000000000683 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2016 Sep;40(9):1217-23. doi: 10.1097/PAS.0000000000000683.