PMID- 27334254
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20170512
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 135
IP  - 5
DP  - 2017 May
TI  - Risk of osteoporotic fractures in multiple sclerosis patients in southwest
      Finland.
PG  - 516-521
LID - 10.1111/ane.12623 [doi]
AB  - OBJECTIVES: Increased risk of osteoporotic fractures in multiple sclerosis (MS)
      patients compared with general population has been reported. The purpose of this 
      study was to assess the risk of osteoporotic and other low-energy fractures in an
      MS cohort from a large hospital district in southwest Finland. Age-adjusted total
      and gender-specific prevalence for definite MS per 100 000 in a population of 472
      139 was calculated as a point prevalence in December 31, 2012. MATERIALS AND
      METHODS: Patients with MS and comorbid fractures were identified by searching for
      ICD-9 and ICD-10 codes during a period from 2004 to 2012 from hospital
      administrative data in Turku University Hospital (TYKS) in southwest Finland Case
      ascertainment was performed by review of medical records. Osteoporotic fracture
      was defined as a low-energy fracture of the pelvis, hip, femur, tibia, humerus,
      collar bone, ulna/radius, vertebrae, or rib. The control population was a 10-fold
      age- and gender-matched population. RESULTS: The point prevalence (N 1004) of MS 
      was 212.6/10(5) (CI 199.5-225.8) in December 31, 2012. A total of 100 (9.9%) of
      1004 confirmed MS cases experienced at least one fracture during the study
      period. Relative risks (RRs) for all fractures (1.33, 95% CI 1.10-1.60) and
      osteoporotic fractures (1.50, 95% CI 1.18-1.90) were significantly increased in
      patients with MS compared with controls. In particular, RRs for hip fractures
      (5.00, 95% CI 2.96-8.43) and fractures of humerus (2.36, 95% CI 1.32-4.42) were
      elevated in patients with MS vs controls. CONCLUSIONS: We observed high
      prevalence of MS in southwest Finland and confirmed increased age-adjusted
      comorbid risk for osteoporotic fractures and other low-energy fractures compared 
      with individually matched controls.
CI  - (c) 2016 John Wiley & Sons A/S.Published by John Wiley & Sons Ltd.
FAU - Aivo, J
AU  - Aivo J
AD  - Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
FAU - Kurki, S
AU  - Kurki S
AD  - Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland.
FAU - Sumelahti, M-L
AU  - Sumelahti ML
AD  - Department of Neurology, Tampere University Hospital, Tampere, Finland.
FAU - Hanninen, K
AU  - Hanninen K
AD  - Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
FAU - Ruutiainen, J
AU  - Ruutiainen J
AD  - Finnish Neuro Society, Masku, Finland.
AD  - University of Turku, Turku, Finland.
FAU - Soilu-Hanninen, M
AU  - Soilu-Hanninen M
AD  - Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
LA  - eng
PT  - Journal Article
DEP - 20160622
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - Finland/epidemiology
MH  - Hip Fractures/diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnosis/*epidemiology
MH  - Osteoporosis/diagnosis/epidemiology
MH  - Osteoporotic Fractures/*diagnosis/*epidemiology
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - falls
OT  - fracture
OT  - multiple sclerosis
OT  - osteoporosis
OT  - prevalence
EDAT- 2016/06/24 06:00
MHDA- 2017/05/13 06:00
CRDT- 2016/06/24 06:00
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/06/24 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
PHST- 2016/06/24 06:00 [entrez]
AID - 10.1111/ane.12623 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2017 May;135(5):516-521. doi: 10.1111/ane.12623. Epub 2016 Jun
      22.