PMID- 27270722
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20180516
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 31
IP  - 10
DP  - 2016 Oct
TI  - Desensitization protocols for prospective pediatric renal transplant recipients.
PG  - 1549-51
LID - 10.1007/s00467-016-3424-3 [doi]
AB  - Desensitization protocols should be considered for children with positive
      crossmatches awaiting renal transplantation. Children are sensitized usually due 
      to previous renal (and/or other solid-organ) transplants but can be from
      administration of blood and/or platelet transfusions, infections, and
      immunizations (as sensitization from pregnancy is a rare occurrence in pediatric 
      patients). However, the definition of HLA-incompatible (HLAi) renal
      transplantation in the literature varies and is best considered only when there
      is a positive cross-match (positive baseline flow cytometric cross-match or
      positive complement-dependent cytotoxic cross-match). Renal transplantation where
      the recipient has donor-specific antibodies (DSA) but a negative cross-match
      should not fall into this category, although they are higher risk.
FAU - Mamode, Nizam
AU  - Mamode N
AD  - Department of Transplantation, Guy's and St Thomas' NHS Foundation Trust, London,
      SE1 9RT, UK. nizam.mamode@gstt.nhs.uk.
AD  - Department of Paediatric Nephrology, Great Ormond Street Hospital for Children
      NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
      nizam.mamode@gstt.nhs.uk.
FAU - Marks, Stephen D
AU  - Marks SD
AD  - Department of Paediatric Nephrology, Great Ormond Street Hospital for Children
      NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PT  - Comment
DEP - 20160606
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (HLA Antigens)
SB  - IM
CON - Pediatr Nephrol. 2016 Oct;31(10 ):1691-8. PMID: 26801944
MH  - Child
MH  - Desensitization, Immunologic/*methods
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Kidney Transplantation/*methods
OTO - NOTNLM
OT  - *Children
OT  - *Cumulative reaction frequency
OT  - *HLA incompatible
OT  - *Panel reactive antibody
OT  - *Renal transplantation
EDAT- 2016/06/09 06:00
MHDA- 2018/01/06 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/04/18 00:00 [received]
PHST- 2016/05/13 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - 10.1007/s00467-016-3424-3 [doi]
AID - 10.1007/s00467-016-3424-3 [pii]
PST - ppublish
SO  - Pediatr Nephrol. 2016 Oct;31(10):1549-51. doi: 10.1007/s00467-016-3424-3. Epub
      2016 Jun 6.