PMID- 27170383
DCOM- 20170117
LR  - 20181202
IS  - 1421-9875 (Electronic)
IS  - 0257-2753 (Linking)
VI  - 34
IP  - 4
DP  - 2016
TI  - Hepatitis E Virus: Time to Change the Textbooks.
PG  - 308-16
LID - 10.1159/000444468 [doi]
AB  - Until recently, hepatitis E virus (HEV) was thought not to occur in developed
      countries. It is now clear that locally acquired HEV is common in such settings. 
      HEV infection acquired in these areas differs from that in developing countries
      in a number of important aspects: it is caused by genotype 3 (and 4 in China and 
      Japan), it mainly affects middle-aged/elderly males and it is zoonotic with a
      porcine primary host. Pig herds worldwide are infected with HEV genotype 3 and
      HEV has been found in the human food chain in a number of developed countries.
      However, the route of transmission is not fully understood, since most cases are 
      not obviously associated with pigs/pig products. HEV can be transmitted by blood 
      transfusion and surprisingly high numbers of asymptomatic blood donors are
      viremic at the time of donation: Germany 1:1,200, Netherlands 1:2,671, England
      1:2,848. Our understanding of the clinical phenotype of HEV infection in humans
      has undergone a sea-change in recent years. Previously, HEV was thought to cause 
      only acute self-limiting hepatitis. However, HEV may cause persistent disease in 
      the immunocompromised. Patients with chronic HEV infection have no symptoms, but 
      some develop rapidly progressive liver cirrhosis. The full clinical spectrum of
      HEV is still emerging. HEV has important extra-hepatic manifestations, which
      deserve further investigation. For example, HEV can cause a wide range of
      neurological illness. In particular, very recent data suggest that Guillain-Barre
      syndrome and neuralgic amyotrophy are associated with locally acquired HEV in
      approximately 5 and 10% of the cases, respectively.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Dalton, Harry R
AU  - Dalton HR
AD  - Royal Cornwall Hospital Trust, Truro, UK.
FAU - Webb, Glynn W
AU  - Webb GW
FAU - Norton, Ben C
AU  - Norton BC
FAU - Woolson, Kathy L
AU  - Woolson KL
LA  - eng
PT  - Journal Article
DEP - 20160511
PL  - Switzerland
TA  - Dig Dis
JT  - Digestive diseases (Basel, Switzerland)
JID - 8701186
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - China
MH  - England
MH  - Female
MH  - Foodborne Diseases/virology
MH  - Genotype
MH  - Germany
MH  - Hepatitis E/*transmission/virology
MH  - Hepatitis E virus/*genetics
MH  - Humans
MH  - Japan
MH  - Liver Cirrhosis/virology
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Swine
MH  - Swine Diseases/transmission/virology
EDAT- 2016/05/14 06:00
MHDA- 2017/01/18 06:00
CRDT- 2016/05/13 06:00
PHST- 2016/05/13 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/01/18 06:00 [medline]
AID - 000444468 [pii]
AID - 10.1159/000444468 [doi]
PST - ppublish
SO  - Dig Dis. 2016;34(4):308-16. doi: 10.1159/000444468. Epub 2016 May 11.