PMID- 27160990
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20170306
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 93
IP  - 4
DP  - 2016
TI  - Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men 
      Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects
      Undergoing Medical Health Checkups.
PG  - 266-71
LID - 10.1159/000445713 [doi]
AB  - BACKGROUND/AIMS: This study aimed at (i) clarifying the factors associated with
      high scores on the modified frequency scale for the symptoms of gastroesophageal 
      reflux disease (FSSG) among 3,505 relatively healthy subjects undergoing routine 
      medical health checkups with gastrointestinal endoscopy and (ii) comparing risk
      factors for high FSSG scores between subjects with and without reflux
      esophagitis. METHODS: In total, 3,505 subjects (male/female: 1,922/1,583) who
      underwent upper gastrointestinal endoscopy during health medical checkups at 5
      hospitals in Saga, Japan from January 2013 to December 2013 were enrolled. All
      subjects completed a modified FSSG questionnaire, which comprised 7 questions
      regarding reflux symptoms and 7 questions regarding acid-related dyspepsia. Each 
      question was assigned a score based on the frequency of symptoms. RESULTS:
      Younger age, female gender, hiatal herniation, and endoscopic reflux esophagitis 
      were risk factors for a FSSG score with a high total. Subjects with high scores
      but without esophagitis were women, and hiatal herniation and Barrett's esophagus
      were frequently seen in patients with reflux esophagitis. CONCLUSION: Younger
      age, female gender, hiatal hernia, and endoscopic esophagitis were risk factors
      for a high FSSG score, and women tended to complain of upper gastrointestinal
      symptoms more frequently than did men among subjects without endoscopic
      esophagitis.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Takeshita, Eri
AU  - Takeshita E
AD  - Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical
      School, Saga, Japan.
FAU - Sakata, Yasuhisa
AU  - Sakata Y
FAU - Hara, Megumi
AU  - Hara M
FAU - Akutagawa, Kayo
AU  - Akutagawa K
FAU - Sakata, Natsuko
AU  - Sakata N
FAU - Endo, Hiroyoshi
AU  - Endo H
FAU - Ohyama, Takashi
AU  - Ohyama T
FAU - Matsunaga, Keiji
AU  - Matsunaga K
FAU - Yoshioka, Tomomi
AU  - Yoshioka T
FAU - Kawakubo, Hirohatu
AU  - Kawakubo H
FAU - Tanaka, Yuichiro
AU  - Tanaka Y
FAU - Shirai, Shimpei
AU  - Shirai S
FAU - Ito, Yoichiro
AU  - Ito Y
FAU - Tsuruoka, Nanae
AU  - Tsuruoka N
FAU - Iwakiri, Ryuichi
AU  - Iwakiri R
FAU - Kusano, Motoyasu
AU  - Kusano M
FAU - Fujimoto, Kazuma
AU  - Fujimoto K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160503
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Barrett Esophagus/diagnosis/*epidemiology
MH  - Cross-Sectional Studies
MH  - Dyspepsia/diagnosis/*epidemiology
MH  - Endoscopy, Gastrointestinal
MH  - Esophagitis, Peptic/diagnosis/*epidemiology
MH  - Female
MH  - Gastroesophageal Reflux/diagnosis/*epidemiology
MH  - Hernia, Hiatal/diagnosis/*epidemiology
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Physical Examination/methods
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Surveys and Questionnaires
EDAT- 2016/05/11 06:00
MHDA- 2017/03/07 06:00
CRDT- 2016/05/11 06:00
PHST- 2015/11/24 00:00 [received]
PHST- 2016/03/18 00:00 [accepted]
PHST- 2016/05/11 06:00 [entrez]
PHST- 2016/05/11 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
AID - 000445713 [pii]
AID - 10.1159/000445713 [doi]
PST - ppublish
SO  - Digestion. 2016;93(4):266-71. doi: 10.1159/000445713. Epub 2016 May 3.