PMID- 27111659
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 4
DP  - 2016
TI  - Stem Cell Therapy for Diabetic Erectile Dysfunction in Rats: A Meta-Analysis.
PG  - e0154341
LID - 10.1371/journal.pone.0154341 [doi]
AB  - INTRODUCTION: Stem cell therapy is a novel method for the treatment of diabetic
      erectile dysfunction (ED). Many relative animal studies have been done to
      evaluate the efficacy of this therapy in rats. AIMS: This meta-analysis was
      performed to compare the efficacy of different stem cell therapies, to evaluate
      the influential factors and to determine the optimal stem cell therapeutic
      strategy for diabetic ED. METHODS: We searched the studies analyzing the efficacy
      of stem cell therapy for diabetic ED in rats published before September 30, 2015 
      in PubMed, Web of Science and EBSCO. A random effects meta-analysis was conducted
      to assess the outcomes of stem cell therapy. Subgroup analysis was also performed
      by separating these studies based on their different characteristics. Changes in 
      the ratio of intracavernous pressure (ICP) to mean arterial pressure (MAP) and in
      the structure of the cavernous body were compared. RESULTS: 10 studies with 302
      rats were enrolled in this meta-analysis. Pooled analysis of these studies showed
      a beneficial effect of stem cell therapy in improving erectile function of
      diabetic rats (SMD 4.03, 95% CI = 3.22 to 4.84, P< 0.001). In the stem cell
      therapy group, both the smooth muscle and endothelium content were much more than
      those in control group. There was also significant increase in the expression of 
      endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase
      (nNOS), the ratio of smooth muscle to collagen, as well as the secretion of
      vascular endothelial growth factor (VEGF). Besides, apoptotic cells were reduced 
      by stem cell treatment. The subgroup analysis indicated that modified stem cells 
      were more effective than those without modification. CONCLUSIONS: Our results
      confirmed that stem cell therapy could apparently improve the erectile function
      of diabetic rats. Some specific modification, especially the gene modification
      with growth factors, could improve the efficacy of stem cell therapy. Stem cell
      therapy has potential to be an effective therapeutic strategy for diabetic ED.
FAU - Li, Mingchao
AU  - Li M
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Li, Hao
AU  - Li H
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Ruan, Yajun
AU  - Ruan Y
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Wang, Tao
AU  - Wang T
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Liu, Jihong
AU  - Liu J
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong
      University of Science and Technology, Wuhan, Hubei, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160425
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Arterial Pressure
MH  - Data Collection
MH  - Diabetes Complications/*therapy
MH  - Diabetes Mellitus, Experimental/complications
MH  - Disease Models, Animal
MH  - Erectile Dysfunction/*therapy
MH  - Male
MH  - Penile Erection
MH  - Penis/physiopathology
MH  - Pressure
MH  - Rats
MH  - *Stem Cell Transplantation
MH  - Stem Cells/cytology
PMC - PMC4844188
EDAT- 2016/04/26 06:00
MHDA- 2017/03/28 06:00
CRDT- 2016/04/26 06:00
PHST- 2016/02/01 00:00 [received]
PHST- 2016/04/11 00:00 [accepted]
PHST- 2016/04/26 06:00 [entrez]
PHST- 2016/04/26 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
AID - 10.1371/journal.pone.0154341 [doi]
AID - PONE-D-15-55017 [pii]
PST - epublish
SO  - PLoS One. 2016 Apr 25;11(4):e0154341. doi: 10.1371/journal.pone.0154341.
      eCollection 2016.