PMID- 27098675
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20170817
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 135
IP  - 3
DP  - 2017 Mar
TI  - Cervical cord and ventricle affection in neuromyelitis optica.
PG  - 324-331
LID - 10.1111/ane.12601 [doi]
AB  - OBJECTIVES: Cervical cord involvement is common in neuromyelitis optica (NMO) and
      multiple sclerosis (MS), but its impact on disability in NMO has rarely been
      studied. Recent publications on NMO examined the periventricular system, areas of
      high aquaporin-4 expression, but not yet by using ventricle volumetry. PURPOSE:
      To compare cervical cord atrophy, ventricular widening, and supra- and
      infratentorial brain measures between NMO and MS, and study their impact on
      clinical disability. METHODS: Magnet resonance imaging-based volumetry of upper
      cervical cord, third and fourth lateral ventricles, grey matter, white matter,
      brainstem, cerebellum and clinical status of 18 NMO and 20 MS patients, was
      compared between the groups and with 26 healthy controls. Patterns of ventricular
      widening relative to healthy controls were inspected by voxel-based morphometry
      of the cerebrospinal fluid. RESULTS: Cervical cord atrophy was similar in NMO and
      MS (75.2 +/- 10.0 mm(2) , respectively, 76.5 +/- 9.5 mm(2) vs 84.1 +/- 8.6 mm(2) 
      in controls).Third ventricle increase in both groups, and specific fourth
      ventricle widening in MS were detected. Patient groups differed in third to
      fourth ventricle ratio (P = 0.002). In NMO, white matter correlated inversely
      with the affected cord segments (P = 0.001) and with cervical cord area (P =
      0.043). The disability status was explained by cervical cord area and third
      ventricle volume (R(2) =0.524) in NMO, and by grey matter and fourth ventricle
      volume (R(2) =0.565) in MS. CONCLUSION: Cervical cord atrophy and third
      ventricular enlargement are both clinically relevant in NMO. Third and fourth
      ventricle volumetry shows differences between NMO and MS regarding the
      involvement of periventricular structures.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Schneider, R
AU  - Schneider R
AD  - Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum,
      Germany.
FAU - Bellenberg, B
AU  - Bellenberg B
AD  - Department of Radiology, St. Josef-Hospital, Ruhr-University Bochum, Bochum,
      Germany.
FAU - Kleiter, I
AU  - Kleiter I
AD  - Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum,
      Germany.
FAU - Gold, R
AU  - Gold R
AD  - Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum,
      Germany.
FAU - Koster, O
AU  - Koster O
AD  - Department of Radiology, St. Josef-Hospital, Ruhr-University Bochum, Bochum,
      Germany.
FAU - Weiler, F
AU  - Weiler F
AD  - Fraunhofer MEVIS Institution for Medical Image Computing, Bremen, Germany.
FAU - Hahn, H
AU  - Hahn H
AD  - Fraunhofer MEVIS Institution for Medical Image Computing, Bremen, Germany.
FAU - Lukas, C
AU  - Lukas C
AD  - Department of Radiology, St. Josef-Hospital, Ruhr-University Bochum, Bochum,
      Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160421
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
SB  - IM
MH  - Adult
MH  - Atrophy/diagnostic imaging
MH  - Cervical Cord/*diagnostic imaging
MH  - Female
MH  - Fourth Ventricle/*diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnostic imaging
MH  - Neuromyelitis Optica/*diagnostic imaging
MH  - Third Ventricle/*diagnostic imaging
OTO - NOTNLM
OT  - *cervical cord atrophy
OT  - *multiple sclerosis
OT  - *neuromyelitis optica
OT  - *ventricle widening
OT  - *voxel-based morphometry
EDAT- 2016/04/22 06:00
MHDA- 2017/02/28 06:00
CRDT- 2016/04/22 06:00
PHST- 2016/03/24 00:00 [accepted]
PHST- 2016/04/22 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
PHST- 2016/04/22 06:00 [entrez]
AID - 10.1111/ane.12601 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2017 Mar;135(3):324-331. doi: 10.1111/ane.12601. Epub 2016 Apr
      21.