PMID- 27016608
OWN - NLM
STAT- MEDLINE
DCOM- 20170728
LR  - 20171109
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 196
IP  - 9
DP  - 2016 May 1
TI  - Cutting Edge: Integrin alpha4 Is Required for Regulatory B Cell Control of
      Experimental Autoimmune Encephalomyelitis.
PG  - 3542-6
LID - 10.4049/jimmunol.1502614 [doi]
AB  - The neutralization of integrin alpha4 (Itga4) is currently used as treatment in
      multiple sclerosis. Although most studies have focused on its function on
      lymphocyte migration to the CNS, we have uncovered the importance of Itga4 for
      the generation of regulatory B cells in peripheral immune organs and their
      control of pathogenic T cell response and CNS pathology. Our study underscores
      the importance of looking at the dual role of B cells in CNS autoimmunity and
      provides important perspectives regarding the efficacy and side effects
      associated with Itga4 neutralization and other B cell-targeting therapies.
CI  - Copyright (c) 2016 by The American Association of Immunologists, Inc.
FAU - Glatigny, Simon
AU  - Glatigny S
AD  - Immunology Program, Benaroya Research Institute, Seattle, WA 98101; and
      Department of Immunology, University of Washington, Seattle, WA 98105.
FAU - Wagner, Catriona A
AU  - Wagner CA
AD  - Department of Immunology, University of Washington, Seattle, WA 98105.
FAU - Bettelli, Estelle
AU  - Bettelli E
AD  - Immunology Program, Benaroya Research Institute, Seattle, WA 98101; and
      Department of Immunology, University of Washington, Seattle, WA 98105
      ebettelli@benaroyaresearch.org.
LA  - eng
GR  - R01 NS081687/NS/NINDS NIH HHS/United States
GR  - R21 NS077116/NS/NINDS NIH HHS/United States
GR  - T32 AI106677/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160325
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 143198-26-9 (Integrin alpha4)
SB  - AIM
SB  - IM
EIN - J Immunol. 2017 May 1;198(9):3756. PMID: 28416719
MH  - Animals
MH  - B-Lymphocytes, Regulatory/*immunology/physiology
MH  - Cell Movement
MH  - Central Nervous System/*immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology/prevention & control
MH  - Humans
MH  - Integrin alpha4/genetics/*immunology
MH  - Mice
MH  - Multiple Sclerosis/immunology
MH  - T-Lymphocytes/immunology
PMC - PMC4868662
MID - NIHMS766429
EDAT- 2016/03/27 06:00
MHDA- 2017/07/29 06:00
CRDT- 2016/03/27 06:00
PHST- 2015/12/17 00:00 [received]
PHST- 2016/03/02 00:00 [accepted]
PHST- 2016/03/27 06:00 [entrez]
PHST- 2016/03/27 06:00 [pubmed]
PHST- 2017/07/29 06:00 [medline]
AID - jimmunol.1502614 [pii]
AID - 10.4049/jimmunol.1502614 [doi]
PST - ppublish
SO  - J Immunol. 2016 May 1;196(9):3542-6. doi: 10.4049/jimmunol.1502614. Epub 2016 Mar
      25.