PMID- 27014874
OWN - NLM
STAT- MEDLINE
DCOM- 20160812
LR  - 20170220
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 3
DP  - 2016
TI  - A Piece of the Puzzle: The Bone Health Index of the BoneXpert Software Reflects
      Cortical Bone Mineral Density in Pediatric and Adolescent Patients.
PG  - e0151936
LID - 10.1371/journal.pone.0151936 [doi]
AB  - INTRODUCTION: Suspected osteopathology in chronically ill children often
      necessitates the assessment of bone mineral density. The most frequently used
      methods are dual-energy X-ray-absorption (DXA) and peripheral quantitative
      computed tomography (pQCT). The BoneXpert software provides an automated
      radiogrammatic method to assess skeletal age from digitalized X-rays of the left 
      hand. Furthermore, the program calculates the Bone Health Index (BHI), a measure 
      of cortical thickness and mineralization, which is obtained from indices of three
      metacarpal bones. In our study, we analyzed the manner in which BHI information
      provided by BoneXpert compares with DXA or pQCT measurements in youths. STUDY
      DESIGN: The BHI was retrospectively obtained using digitalized X-rays of the left
      hand and compared with the results of 203 corresponding DXA readings (Lunar
      Prodigy, GE Healthcare) of the lumbar vertebrae and femur as well as 117 pQCT
      readings (XCT 900, Stratec) of the distal radius. RESULTS: The BHI values showed 
      a strong positive correlation with the DXA readings at each and all lumbar
      vertebrae (L1 -L4: r = 0.73; P < 0.0001). The age-adjusted Z-score of L1 -L4 and 
      the height-adjusted score showed a positive correlation with the BHI-SDS
      (standard deviation score, r = 0.23; P < 0.002 and r = 0.27; P < 0.001,
      respectively). Total bone mineral density, as assessed via pQCT, also positively 
      correlated with the BHI (r = 0.39; P < 0.0001), but the trabecular values
      displayed only a weak correlation. CONCLUSIONS: The BHI obtained using BoneXpert 
      can be a useful parameter in the assessment of bone health in children in most
      cases. This technique provides observer-independent information on cortical
      thickness and mineralization based on X-ray imaging of the hands.
FAU - Schundeln, Michael M
AU  - Schundeln MM
AD  - Pediatric Hematology and Oncology, Kinderklinik III, Universitatsklinikum-Essen
      and the University of Duisburg-Essen, Essen, Germany.
FAU - Marschke, Laura
AU  - Marschke L
AD  - Pediatric Endocrinology and Diabetology, Kinderklinik II,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
FAU - Bauer, Jens J
AU  - Bauer JJ
AD  - Pediatric Hematology and Oncology, Kinderklinik III, Universitatsklinikum-Essen
      and the University of Duisburg-Essen, Essen, Germany.
AD  - Pediatric Endocrinology and Diabetology, Kinderklinik II,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
FAU - Hauffa, Pia K
AU  - Hauffa PK
AD  - Pediatric Hematology and Oncology, Kinderklinik III, Universitatsklinikum-Essen
      and the University of Duisburg-Essen, Essen, Germany.
FAU - Schweiger, Bernd
AU  - Schweiger B
AD  - Institute of Diagnostic and Interventional Radiology and Neuroradiology,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
FAU - Fuhrer-Sakel, Dagmar
AU  - Fuhrer-Sakel D
AD  - Department of Endocrinology and Metabolism, Medical Center,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
FAU - Lahner, Harald
AU  - Lahner H
AD  - Department of Endocrinology and Metabolism, Medical Center,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
FAU - Poeppel, Thorsten D
AU  - Poeppel TD
AD  - Clinik for Nuclear Medicine, Universitatsklinikum-Essen and the University of
      Duisburg-Essen, Essen, Germany.
FAU - Kiewert, Cordula
AU  - Kiewert C
AD  - Pediatric Endocrinology and Diabetology, Kinderklinik II,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
FAU - Hauffa, Berthold P
AU  - Hauffa BP
AD  - Pediatric Endocrinology and Diabetology, Kinderklinik II,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
FAU - Grasemann, Corinna
AU  - Grasemann C
AD  - Pediatric Endocrinology and Diabetology, Kinderklinik II,
      Universitatsklinikum-Essen and the University of Duisburg-Essen, Essen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160325
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 1406-16-2 (Vitamin D)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - Adult
MH  - *Bone Density
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Femur/*diagnostic imaging/metabolism/pathology
MH  - Humans
MH  - Male
MH  - Osteoporosis/*diagnostic imaging/metabolism/pathology
MH  - Phosphoric Monoester Hydrolases/metabolism
MH  - Retrospective Studies
MH  - Software
MH  - *Tomography, X-Ray Computed
MH  - Vitamin D/metabolism
PMC - PMC4807844
EDAT- 2016/03/26 06:00
MHDA- 2016/08/16 06:00
CRDT- 2016/03/26 06:00
PHST- 2015/11/30 00:00 [received]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/03/26 06:00 [entrez]
PHST- 2016/03/26 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - 10.1371/journal.pone.0151936 [doi]
AID - PONE-D-15-52059 [pii]
PST - epublish
SO  - PLoS One. 2016 Mar 25;11(3):e0151936. doi: 10.1371/journal.pone.0151936.
      eCollection 2016.