PMID- 26915845
OWN - NLM
STAT- MEDLINE
DCOM- 20161107
LR  - 20170103
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 48
IP  - 1
DP  - 2016 Jan-Feb
TI  - Cardiac Events After Kidney Transplantation According to Pretransplantation
      Coronary Artery Disease and Coronary Revascularization Status.
PG  - 65-73
LID - 10.1016/j.transproceed.2015.12.028 [doi]
LID - S0041-1345(15)01215-4 [pii]
AB  - OBJECTIVES: The aims of this study were to compare the rates of cardiovascular
      events among renal transplant recipients according to pre-transplantation
      coronary artery disease (CAD) and revascularization status and to describe the
      coronary angiographic findings in patients with post-transplantation events.
      METHODS: This was a retrospective cohort study of patients who had coronary
      angiography within 2 years before kidney transplantation. The predictor variables
      were pre-transplantation CAD and coronary revascularization. The primary outcome 
      was a composite of cardiovascular mortality, acute coronary syndrome, and
      post-transplantation revascularization. RESULTS: The study included 403 patients.
      Pre-transplantation CAD was present in 73%, and 22% were revascularized. During a
      follow-up period of 5.6 years, the primary outcome occurred in 5% of the subjects
      without CAD, in 23% of those with CAD and no revascularization, and in 26% of
      those with CAD and revascularization (CAD hazard ratio [HR], 4.39 [P = .002];
      revascularization HR, 1.27 [P = .36]). Thirty-five patients had a primary outcome
      and repeated coronary angiography, which demonstrated progression of previously
      nonsevere disease in the majority of cases. CONCLUSIONS: Adverse cardiovascular
      outcomes are common after renal transplantation and are associated with
      pre-transplantation CAD of any severity. Secondary prevention of CAD events
      should be a high priority in the management of this high-risk population.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Felix, R
AU  - Felix R
AD  - Cardiology and Nephrology Departments, Kaiser San Francisco Medical Center, San
      Francisco, California.
FAU - Saparia, T
AU  - Saparia T
AD  - Cardiology and Nephrology Departments, Kaiser San Francisco Medical Center, San
      Francisco, California.
FAU - Hirose, R
AU  - Hirose R
AD  - Division of Transplant Surgery, University of California, San Francisco,
      California.
FAU - Almers, L
AU  - Almers L
AD  - Division of Research, Kaiser Oakland Medical Center, Oakland, California.
FAU - Chau, Q
AU  - Chau Q
AD  - Cardiology and Nephrology Departments, Kaiser San Francisco Medical Center, San
      Francisco, California.
FAU - Jonelis, T
AU  - Jonelis T
AD  - Cardiology and Nephrology Departments, Kaiser San Francisco Medical Center, San
      Francisco, California.
FAU - Zheng, S
AU  - Zheng S
AD  - Nephrology Department, Kaiser Oakland Medical Center, Oakland, California.
FAU - Zaroff, J
AU  - Zaroff J
AD  - Division of Research, Kaiser Oakland Medical Center, Oakland, California.
      Electronic address: jonathan.g.zaroff@kp.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Aged
MH  - California
MH  - Coronary Angiography/statistics & numerical data
MH  - Coronary Artery Disease/*complications/diagnostic imaging/therapy
MH  - Disease Progression
MH  - Endovascular Procedures/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*etiology
MH  - Preoperative Period
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Severity of Illness Index
EDAT- 2016/02/27 06:00
MHDA- 2016/11/08 06:00
CRDT- 2016/02/27 06:00
PHST- 2015/11/16 00:00 [received]
PHST- 2015/12/30 00:00 [accepted]
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2016/11/08 06:00 [medline]
AID - S0041-1345(15)01215-4 [pii]
AID - 10.1016/j.transproceed.2015.12.028 [doi]
PST - ppublish
SO  - Transplant Proc. 2016 Jan-Feb;48(1):65-73. doi:
      10.1016/j.transproceed.2015.12.028.