PMID- 26892983
OWN - NLM
STAT- MEDLINE
DCOM- 20170927
LR  - 20180815
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 37
IP  - 6
DP  - 2016 Jun
TI  - Autoimmune Comorbidities Are Associated with Brain Injury in Multiple Sclerosis.
PG  - 1010-6
LID - 10.3174/ajnr.A4681 [doi]
AB  - BACKGROUND AND PURPOSE: The effect of comorbidities on disease severity in MS has
      not been extensively characterized. We determined the association of
      comorbidities with MR imaging disease severity outcomes in MS. MATERIALS AND
      METHODS: Demographic and clinical history of 9 autoimmune comorbidities confirmed
      by retrospective chart review and quantitative MR imaging data were obtained in
      815 patients with MS. The patients were categorized on the basis of the
      presence/absence of total and specific comorbidities. We analyzed the MR imaging 
      findings, adjusting for key covariates and correcting for multiple comparisons.
      RESULTS: Two hundred forty-one (29.6%) study subjects presented with
      comorbidities. Thyroid disease had the highest frequency (n = 97, 11.9%),
      followed by asthma (n = 41, 5%), type 2 diabetes mellitus (n = 40, 4.9%),
      psoriasis (n = 33, 4%), and rheumatoid arthritis (n = 22, 2.7%). Patients with MS
      with comorbidities showed decreased whole-brain and cortical volumes (P < .001), 
      gray matter volume and magnetization transfer ratio of normal-appearing brain
      tissue (P < .01), and magnetization transfer ratio of gray matter (P < .05).
      Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities were
      associated with decreased whole-brain, cortical, and gray matter volumes (P <
      .05). Psoriasis was associated with a decreased magnetization transfer ratio of
      normal-appearing brain tissue (P < .05), while type 2 diabetes mellitus was
      associated with increased mean diffusivity (P < .01). CONCLUSIONS: The presence
      of comorbidities in patients with MS is associated with brain injury on MR
      imaging. Psoriasis, thyroid disease, and type 2 diabetes mellitus comorbidities
      were associated with more severe nonconventional MR imaging outcomes.
CI  - (c) 2016 by American Journal of Neuroradiology.
FAU - Zivadinov, R
AU  - Zivadinov R
AUID- ORCID: 0000-0002-7799-1485
AD  - From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo
      Neuroimaging Analysis Center MR Imaging Clinical Translational Research Center
      (R.Z.) rzivadinov@bnac.net.
FAU - Raj, B
AU  - Raj B
AUID- ORCID: 0000-0002-3092-4576
AD  - From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo
      Neuroimaging Analysis Center.
FAU - Ramanathan, M
AU  - Ramanathan M
AUID- ORCID: 0000-0002-9943-150X
AD  - Department of Pharmaceutical Sciences (M.R.), School of Medicine and Biomedical
      Sciences, State University of New York, Buffalo, New York.
FAU - Teter, B
AU  - Teter B
AUID- ORCID: 0000-0003-1527-6192
AD  - Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center,
      University at Buffalo, State University of New York, Buffalo, New York.
FAU - Durfee, J
AU  - Durfee J
AUID- ORCID: 0000-0002-9571-975X
AD  - From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo
      Neuroimaging Analysis Center.
FAU - Dwyer, M G
AU  - Dwyer MG
AUID- ORCID: 0000-0003-4684-4658
AD  - From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo
      Neuroimaging Analysis Center.
FAU - Bergsland, N
AU  - Bergsland N
AUID- ORCID: 0000-0002-7792-0433
AD  - From the, Department of Neurology (R.Z., B.R., J.D., M.G.D., N.B.), Buffalo
      Neuroimaging Analysis Center Magnetic Resonance Laboratory (N.B.), IRCCS Don
      Gnocchi Foundation, Milan, Italy.
FAU - Kolb, C
AU  - Kolb C
AUID- ORCID: 0000-0001-7761-2548
AD  - Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center,
      University at Buffalo, State University of New York, Buffalo, New York.
FAU - Hojnacki, D
AU  - Hojnacki D
AUID- ORCID: 0000-0002-2518-848X
AD  - Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center,
      University at Buffalo, State University of New York, Buffalo, New York.
FAU - Benedict, R H
AU  - Benedict RH
AUID- ORCID: 0000-0002-2080-3631
AD  - Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center,
      University at Buffalo, State University of New York, Buffalo, New York.
FAU - Weinstock-Guttman, B
AU  - Weinstock-Guttman B
AUID- ORCID: 0000-0001-6732-151X
AD  - Department of Neurology (B.T., C.K., D.H., R.H.B., B.W.-G.), Jacobs MS Center,
      University at Buffalo, State University of New York, Buffalo, New York.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, Non-U.S. Gov't
DEP - 20160218
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
SB  - IM
MH  - Adult
MH  - Autoimmune Diseases/*epidemiology
MH  - Brain/*pathology
MH  - Brain Injuries
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*complications/*pathology
MH  - Retrospective Studies
EDAT- 2016/02/20 06:00
MHDA- 2017/09/28 06:00
CRDT- 2016/02/20 06:00
PHST- 2015/10/02 00:00 [received]
PHST- 2015/11/25 00:00 [accepted]
PHST- 2016/02/20 06:00 [entrez]
PHST- 2016/02/20 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
AID - ajnr.A4681 [pii]
AID - 10.3174/ajnr.A4681 [doi]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2016 Jun;37(6):1010-6. doi: 10.3174/ajnr.A4681. Epub 2016 
      Feb 18.