PMID- 26658667
OWN - NLM
STAT- MEDLINE
DCOM- 20160411
LR  - 20151215
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 40
IP  - 1
DP  - 2016 Jan
TI  - High-grade Transformation of Low-grade B-cell Lymphoma: Pathology and Molecular
      Pathogenesis.
PG  - e1-16
LID - 10.1097/PAS.0000000000000561 [doi]
AB  - Patients with low-grade (clinically indolent) lymphomas are at risk to undergo
      transformation to high-grade (clinically aggressive) lymphoma, although
      transformation only occurs in a subset of patients. When transformation occurs it
      is a critical event that determines the course of disease and is associated with 
      unfavorable patient outcomes. Accurate detection of transformation, predictive
      biomarkers, and identification of specific molecular pathways implicated in the
      pathobiology of transformation will facilitate personalized therapeutic
      approaches and underpin advances in clinical outcomes. In this article, we
      present an update of the clinical and pathologic diagnostic criteria for
      low-grade B-cell lymphoma transformation and discuss the molecular alterations
      involved in the pathogenesis of this biological phenomenon.
FAU - Agbay, Rose Lou Marie C
AU  - Agbay RL
AD  - Department of Hematopathology, The University of Texas MD Anderson Cancer Center,
      Houston, TX.
FAU - Loghavi, Sanam
AU  - Loghavi S
FAU - Medeiros, L Jeffrey
AU  - Medeiros LJ
FAU - Khoury, Joseph D
AU  - Khoury JD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biomarkers, Tumor/genetics/immunology
MH  - Biopsy
MH  - *Cell Transformation, Neoplastic/genetics/immunology/pathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Lymphoma, B-Cell/*diagnosis/genetics/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - *Molecular Diagnostic Techniques
MH  - Neoplasm Grading
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Risk Assessment
MH  - Risk Factors
MH  - Young Adult
EDAT- 2015/12/15 06:00
MHDA- 2016/04/12 06:00
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2016/04/12 06:00 [medline]
AID - 10.1097/PAS.0000000000000561 [doi]
AID - 00000478-201601000-00001 [pii]
PST - ppublish
SO  - Am J Surg Pathol. 2016 Jan;40(1):e1-16. doi: 10.1097/PAS.0000000000000561.