PMID- 26493322
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20151107
IS  - 1753-4887 (Electronic)
IS  - 0029-6643 (Linking)
VI  - 73
IP  - 12
DP  - 2015 Dec
TI  - Glutathionyl systems and metabolic dysfunction in obesity.
PG  - 858-68
LID - 10.1093/nutrit/nuv042 [doi]
AB  - Oxidative stress is associated with obesity. However, glutathione (GSH), one of
      the body's most abundant antioxidants, plays dual and seemingly contradictory
      roles in the development of obesity and its comorbidities. Glutathione has
      complex metabolic and biochemical fates and is a cofactor for several enzymes
      that function in modifying obesity-related responses. For example, depletion of
      GSH increases energy metabolism and reduces adipose accretion, while elevation of
      GSH peroxidase activity induces insulin resistance. This review summarizes the
      literature linking GSH and its related enzymes, GSH peroxidase, glutaredoxins,
      and glutathione S-transferases, to obesity and its pertinent endpoints (e.g.,
      energy metabolism, inflammation, and insulin resistance).
CI  - Published by Oxford University Press on behalf of the International Life Sciences
      Institute 2015. This work is written by US Government employees and is in the
      public domain in the US.
FAU - Picklo, Matthew J
AU  - Picklo MJ
AD  - M.J. Picklo and E.E. Vomhof-DeKrey are with the Grand Forks Human Nutrition
      Research Center, USDA-ARS, Grand Forks, North Dakota, USA. M.J. Picklo is with
      the Department of Chemistry, University of North Dakota, Grand Forks, North
      Dakota, USA. E.K. Long is with the Department of Surgery, University of
      Minnesota, Minneapolis, Minnesota USA. matthew.picklo@ars.usda.gov.
FAU - Long, Eric K
AU  - Long EK
AD  - M.J. Picklo and E.E. Vomhof-DeKrey are with the Grand Forks Human Nutrition
      Research Center, USDA-ARS, Grand Forks, North Dakota, USA. M.J. Picklo is with
      the Department of Chemistry, University of North Dakota, Grand Forks, North
      Dakota, USA. E.K. Long is with the Department of Surgery, University of
      Minnesota, Minneapolis, Minnesota USA.
FAU - Vomhof-DeKrey, Emilie E
AU  - Vomhof-DeKrey EE
AD  - M.J. Picklo and E.E. Vomhof-DeKrey are with the Grand Forks Human Nutrition
      Research Center, USDA-ARS, Grand Forks, North Dakota, USA. M.J. Picklo is with
      the Department of Chemistry, University of North Dakota, Grand Forks, North
      Dakota, USA. E.K. Long is with the Department of Surgery, University of
      Minnesota, Minneapolis, Minnesota USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20151022
PL  - United States
TA  - Nutr Rev
JT  - Nutrition reviews
JID - 0376405
RN  - 0 (Antioxidants)
RN  - EC 1.- (Oxidoreductases)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Antioxidants
MH  - Glutathione/*metabolism
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - *Obesity/metabolism/physiopathology
MH  - Oxidative Stress
MH  - Oxidoreductases/metabolism
OTO - NOTNLM
OT  - glutathione
OT  - glutathione S-transferase
OT  - glutathione peroxidase
OT  - glutathionylation
OT  - inflammation.
OT  - insulin
OT  - obesity
EDAT- 2015/10/24 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/10/24 06:00
PHST- 2015/05/21 00:00 [received]
PHST- 2015/04/18 00:00 [accepted]
PHST- 2015/10/24 06:00 [entrez]
PHST- 2015/10/24 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - nuv042 [pii]
AID - 10.1093/nutrit/nuv042 [doi]
PST - ppublish
SO  - Nutr Rev. 2015 Dec;73(12):858-68. doi: 10.1093/nutrit/nuv042. Epub 2015 Oct 22.