PMID- 26419612
OWN - NLM
STAT- MEDLINE
DCOM- 20160624
LR  - 20171024
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 127
IP  - 2
DP  - 2016 Feb
TI  - Bradysomnia in Parkinson's disease.
PG  - 1403-1409
LID - S1388-2457(15)00787-7 [pii]
LID - 10.1016/j.clinph.2015.08.012 [doi]
AB  - OBJECTIVE: Polysomnography studies in Parkinson's disease (PD) patients show
      altered sleep microstructure with decreased level of arousability, indicating
      impaired sleep-wake dynamics in PD. The aim of this study was to investigate
      dynamical aspects of sleep EEG in PD as compared to healthy controls. METHODS: In
      this retrospective, controlled study, we applied a previously established
      mathematical model of sleep EEG analysis (state space model) to PD patients and
      age- and gender-matched healthy volunteers (N=64). Dynamical aspects of sleep
      were quantified by measuring the spectral variability of the sleep EEG (by means 
      of state space velocity). RESULTS: State space analysis revealed preserved global
      sleep-wake architecture in PD patients, but the velocity of sleep stage
      transitions was significantly reduced as compared to healthy controls.
      Correlation analysis revealed a strong association of state space velocity with
      arousal scores and daily dopamine agonist intake. CONCLUSIONS: Quantitative
      analysis of spectral sleep EEG variability (state space velocity) revealed
      reduced sleep-wake dynamics in PD patients as compared to control subjects.
      SIGNIFICANCE: We propose state space velocity as an objective and quantitative
      measure for altered sleep microstructure and as a potential biomarker of sleep
      alterations in PD, not accessible by conventional sleep analysis.
CI  - Copyright (c) 2015 International Federation of Clinical Neurophysiology.
      Published by Elsevier Ireland Ltd. All rights reserved.
FAU - Imbach, Lukas L
AU  - Imbach LL
AD  - Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091
      Zurich, Switzerland. Electronic address: lukas.imbach@usz.ch.
FAU - Sommerauer, Michael
AU  - Sommerauer M
AD  - Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091
      Zurich, Switzerland.
FAU - Poryazova, Rositsa
AU  - Poryazova R
AD  - Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091
      Zurich, Switzerland.
FAU - Werth, Esther
AU  - Werth E
AD  - Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091
      Zurich, Switzerland.
FAU - Valko, Philipp O
AU  - Valko PO
AD  - Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091
      Zurich, Switzerland.
FAU - Scammell, Thomas E
AU  - Scammell TE
AD  - Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, 
      USA.
FAU - Baumann, Christian R
AU  - Baumann CR
AD  - Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091
      Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150902
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*diagnosis/*epidemiology
MH  - Polysomnography/methods
MH  - Retrospective Studies
MH  - Sleep Wake Disorders/*diagnosis/*epidemiology
OTO - NOTNLM
OT  - EEG
OT  - Parkinson's disease
OT  - Sleep
OT  - Spectral analysis
OT  - State space model
EDAT- 2015/10/01 06:00
MHDA- 2016/06/25 06:00
CRDT- 2015/10/01 06:00
PHST- 2015/06/19 00:00 [received]
PHST- 2015/08/04 00:00 [revised]
PHST- 2015/08/25 00:00 [accepted]
PHST- 2015/10/01 06:00 [entrez]
PHST- 2015/10/01 06:00 [pubmed]
PHST- 2016/06/25 06:00 [medline]
AID - S1388-2457(15)00787-7 [pii]
AID - 10.1016/j.clinph.2015.08.012 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2016 Feb;127(2):1403-1409. doi: 10.1016/j.clinph.2015.08.012. 
      Epub 2015 Sep 2.