PMID- 26380951
OWN - NLM
STAT- MEDLINE
DCOM- 20161021
LR  - 20170220
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 31
IP  - 1
DP  - 2016 Jan
TI  - Striatal and Cortical beta-Amyloidopathy and Cognition in Parkinson's Disease.
PG  - 111-7
LID - 10.1002/mds.26369 [doi]
AB  - INTRODUCTION: Although most previous cognitive studies of beta-amyloidopathy in
      PD focused on cortical plaque deposition, recent postmortem studies point to an
      important role of striatal beta-amyloid plaque deposition. The aim of this study 
      was to investigate the relative contributions of striatal and cortical
      beta-amyloidopathy to cognitive impairment in PD. METHODS: Patients with PD (n = 
      62; age, 68.9 +/- 6.4 years; H & Y stage: 2.7 +/- 0.5; MoCA score: 25.2 +/- 3.0) 
      underwent [(11) C]Pittsburgh compound B beta-amyloid, [(11)
      C]dihydrotetrabenazine monoaminergic, and [(11) C]methyl-4-piperidinyl propionate
      acetylcholinesterase brain PET imaging and neuropsychological assessment. [(11)
      C]Pittsburgh compound B beta-amyloid data from young to middle-aged healthy
      subjects were used to define elevated [(11) C]Pittsburgh compound B binding in
      patients. RESULTS: Elevated cortical and striatal beta-amyloid deposition were
      present in 37% and 16%, respectively, of this predominantly nondemented cohort of
      patients with PD. Increased striatal beta-amyloid deposition occurred in half of 
      all subjects with increased cortical beta-amyloid deposition. In contrast,
      increased striatal beta-amyloid deposition did not occur in the absence of
      increased cortical beta-amyloid deposition. Analysis of covariance using global
      composite cognitive z scores as the outcome parameter showed significant
      regressor effects for combined striatal and cortical beta-amyloidopathy (F =
      4.18; P = 0.02) after adjusting for covariate effects of cortical cholinergic
      activity (F = 5.67; P = 0.02), caudate nucleus monoaminergic binding, duration of
      disease, and age (total model: F = 3.55; P = 0.0048). Post-hoc analysis showed
      significantly lower cognitive z score for combined striatal and cortical
      beta-amyloidopathy, compared to cortical-only beta-amyloidopathy and
      non-beta-amyloidopathy subgroups. CONCLUSIONS: The combined presence of striatal 
      and cortical beta-amyloidopathy is associated with greater cognitive impairment
      than cortical beta-amyloidopathy alone in PD.
CI  - (c) 2015 International Parkinson and Movement Disorder Society.
FAU - Shah, Neha
AU  - Shah N
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
FAU - Frey, Kirk A
AU  - Frey KA
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
AD  - Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
FAU - Muller, Martijn L T M
AU  - Muller ML
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
AD  - University of Michigan Morris K. Udall Center, Ann Arbor, Michigan, USA.
FAU - Petrou, Myria
AU  - Petrou M
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
FAU - Kotagal, Vikas
AU  - Kotagal V
AD  - Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
FAU - Koeppe, Robert A
AU  - Koeppe RA
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
AD  - University of Michigan Morris K. Udall Center, Ann Arbor, Michigan, USA.
FAU - Scott, Peter J H
AU  - Scott PJ
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
FAU - Albin, Roger L
AU  - Albin RL
AD  - Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
AD  - Neurology Service and GRECC, VAAAHS, Ann Arbor, Michigan, USA.
AD  - University of Michigan Morris K. Udall Center, Ann Arbor, Michigan, USA.
FAU - Bohnen, Nicolaas I
AU  - Bohnen NI
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
AD  - Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
AD  - Neurology Service and GRECC, VAAAHS, Ann Arbor, Michigan, USA.
AD  - University of Michigan Morris K. Udall Center, Ann Arbor, Michigan, USA.
LA  - eng
GR  - I01 RX000317/RX/RRD VA/United States
GR  - P01 NS015655/NS/NINDS NIH HHS/United States
GR  - P50 NS091856/NS/NINDS NIH HHS/United States
GR  - R01 NS070856/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150918
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Aniline Compounds)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Thiazoles)
RN  - 3466-75-9 (dihydrotetrabenazine)
RN  - Z9O08YRN8O (Tetrabenazine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloid beta-Peptides/*metabolism
MH  - Analysis of Variance
MH  - Aniline Compounds/pharmacokinetics
MH  - Carbon Isotopes/pharmacokinetics
MH  - Cerebral Cortex/*metabolism
MH  - Cognition Disorders/diagnostic imaging/*etiology/*pathology
MH  - Corpus Striatum/*metabolism
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*complications/diagnostic imaging
MH  - Positron-Emission Tomography
MH  - Tetrabenazine/analogs & derivatives/pharmacokinetics
MH  - Thiazoles/pharmacokinetics
PMC - PMC4724301
MID - NIHMS710561
OTO - NOTNLM
OT  - PET
OT  - Parkinson's disease
OT  - acetylcholinesterase
OT  - cognitive impairment
OT  - cortex
OT  - dopamine
OT  - striatum
OT  - beta-amyloid
EDAT- 2015/09/19 06:00
MHDA- 2016/10/22 06:00
CRDT- 2015/09/19 06:00
PHST- 2015/04/01 00:00 [received]
PHST- 2015/07/15 00:00 [revised]
PHST- 2015/07/17 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2016/10/22 06:00 [medline]
AID - 10.1002/mds.26369 [doi]
PST - ppublish
SO  - Mov Disord. 2016 Jan;31(1):111-7. doi: 10.1002/mds.26369. Epub 2015 Sep 18.