PMID- 26371781
OWN - NLM
STAT- MEDLINE
DCOM- 20160126
LR  - 20171116
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 39
IP  - 11
DP  - 2015 Nov
TI  - Intralymphatic Spread Is a Common Finding in Cutaneous CD30+ Lymphoproliferative 
      Disorders.
PG  - 1511-7
LID - 10.1097/PAS.0000000000000474 [doi]
AB  - An intralymphatic variant of the cutaneous CD30 lymphoproliferative disorders
      (cutaneous anaplastic large cell lymphoma [ALCL] and lymphomatoid papulosis
      [LyP]) has been described recently. We retrieved 60 cases of ALCL of the skin
      (primary cutaneous: 37; cases with concomitant involvement of 1 regional lymph
      node: 4; skin involvement from systemic disease: 4; cases with staging results
      unknown: 15) and 16 cases of LyP, to evaluate the presence of lymphatic vessel
      involvement by neoplastic cells. A D2-40 immunohistochemical staining was used to
      highlight lymphatic vessels. Lymphatic vessel involvement was found in 36 cases
      (60%) of ALCL (primary cutaneous: 24; concomitant: 3; secondary cutaneous: 4;
      staging unknown: 5), and in 6 cases (37.5%) of LyP. Follow-up data, available in 
      28 patients with ALCL and 11 with LyP, suggested that lymphatic vessel
      involvement had no negative prognostic implication. Our study demonstrates that
      cutaneous CD30 lymphoproliferative disorders are frequently characterized by
      involvement of the lymphatic vessels. The intralymphatic variant of ALCL and LyP 
      may be explained, at least in part, by a particular lymphotropism of the
      neoplastic cells of cutaneous CD30 lymphoproliferative disorders.
FAU - Ferrara, Gerardo
AU  - Ferrara G
AD  - *Research Unit Dermatopathology, Department of Dermatology, Medical University of
      Graz, Graz, Austria daggerAnatomic Pathology Unit, Gaetano Rummo Hospital,
      Benevento double daggerDermatology Unit, University of Sassari, Sassari section
      signDepartment of Dermatopathology, San Gallicano Dermatology Institute, Rome,
      Italy.
FAU - Ena, Luca
AU  - Ena L
FAU - Cota, Carlo
AU  - Cota C
FAU - Cerroni, Lorenzo
AU  - Cerroni L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Antibodies, Monoclonal, Murine-Derived)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Ki-1 Antigen)
RN  - 0 (monoclonal antibody D2-40)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal, Murine-Derived
MH  - Biomarkers, Tumor/*analysis
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-1 Antigen/*analysis
MH  - Lymphatic Metastasis
MH  - Lymphatic Vessels/*immunology/*pathology
MH  - Lymphoma, Primary Cutaneous Anaplastic Large Cell/*immunology/*pathology
MH  - Lymphomatoid Papulosis/*immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Skin Neoplasms/*immunology/*pathology
EDAT- 2015/09/16 06:00
MHDA- 2016/01/27 06:00
CRDT- 2015/09/16 06:00
PHST- 2015/09/16 06:00 [entrez]
PHST- 2015/09/16 06:00 [pubmed]
PHST- 2016/01/27 06:00 [medline]
AID - 10.1097/PAS.0000000000000474 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2015 Nov;39(11):1511-7. doi: 10.1097/PAS.0000000000000474.