PMID- 26228878
OWN - NLM
STAT- MEDLINE
DCOM- 20160613
LR  - 20151114
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 36
IP  - 11
DP  - 2015 Nov
TI  - Ultra-High-Field MRI Visualization of Cortical Multiple Sclerosis Lesions with T2
      and T2*: A Postmortem MRI and Histopathology Study.
PG  - 2062-7
LID - 10.3174/ajnr.A4418 [doi]
AB  - BACKGROUND AND PURPOSE: At 7T MR imaging, T2*-weighted gradient echo has been
      shown to provide high-resolution anatomic images of gray matter lesions. However,
      few studies have verified T2*WI lesions histopathologically or compared them with
      more standard techniques at ultra-high-field strength. This study aimed to
      determine the sensitivity of T2WI and T2*WI sequences for detecting cortical GM
      lesions in MS. MATERIALS AND METHODS: At 7T, 2D multiecho spin-echo T2WI and 3D
      gradient-echo T2*WI were acquired from 27 formalin-fixed coronal hemispheric
      brain sections of 15 patients and 4 healthy controls. Proteolipid-stained tissue 
      sections (8 mum) were matched to the corresponding MR images, and lesions were
      manually scored on both MR imaging sequences (blinded to histopathology) and
      tissue sections (blinded to MR imaging). The sensitivity of MR imaging sequences 
      for GM lesion types and white matter lesions was calculated. An unblinded
      retrospective scoring was also performed. RESULTS: If all cortical GM lesions
      were taken into account, the T2WI sequence detected slightly more lesions than
      the T2*WI sequence: 28% and 16%, respectively (P = .054). This difference
      disappeared when only intracortical lesions were considered. When histopathologic
      information (type, location) was revealed to the reader, the sensitivity went up 
      to 84% (T2WI) and 85% (T2*WI) (not significant). Furthermore, the false-positive 
      rate was 8.6% for the T2WI and 10.5% for the T2*WI sequence. CONCLUSIONS: There
      is no strong advantage of the T2*WI sequence compared with a conventional T2WI
      sequence in the detection of cortical lesions at 7T. Retrospectively, a high
      percentage of lesions could be detected with both sequences. However, many
      lesions are still missed prospectively. This could possibly be minimized with
      better a priori observer training.
CI  - (c) 2015 by American Journal of Neuroradiology.
FAU - Jonkman, L E
AU  - Jonkman LE
AD  - From the Department of Anatomy and Neurosciences (L.E.J., R.K., J.J.G.G.), VU
      University Medical Center, Amsterdam, the Netherlands le.jonkman@vumc.nl.
FAU - Klaver, R
AU  - Klaver R
AD  - From the Department of Anatomy and Neurosciences (L.E.J., R.K., J.J.G.G.), VU
      University Medical Center, Amsterdam, the Netherlands.
FAU - Fleysher, L
AU  - Fleysher L
AD  - Departments of Radiology (L.F., M.I.).
FAU - Inglese, M
AU  - Inglese M
AD  - Departments of Radiology (L.F., M.I.) Neurology (M.I.) Neurosciences (M.I.),
      Mount Sinai School of Medicine, New York, New York Departments of Neuroscience,
      Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (M.I.),
      University of Genoa, Genoa, Italy.
FAU - Geurts, J J G
AU  - Geurts JJ
AD  - From the Department of Anatomy and Neurosciences (L.E.J., R.K., J.J.G.G.), VU
      University Medical Center, Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150730
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
SB  - IM
MH  - Adult
MH  - Autopsy
MH  - Brain/*pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*pathology
MH  - Neuroimaging/*methods
MH  - Retrospective Studies
EDAT- 2015/08/01 06:00
MHDA- 2016/06/14 06:00
CRDT- 2015/08/01 06:00
PHST- 2015/02/23 00:00 [received]
PHST- 2015/04/02 00:00 [accepted]
PHST- 2015/08/01 06:00 [entrez]
PHST- 2015/08/01 06:00 [pubmed]
PHST- 2016/06/14 06:00 [medline]
AID - ajnr.A4418 [pii]
AID - 10.3174/ajnr.A4418 [doi]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2015 Nov;36(11):2062-7. doi: 10.3174/ajnr.A4418. Epub 2015
      Jul 30.