PMID- 26093705
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20150623
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 47
IP  - 5
DP  - 2015 Jun
TI  - Urologic Disorders in Living Renal Donors and Outcomes of Their Recipients.
PG  - 1306-8
LID - 10.1016/j.transproceed.2015.04.068 [doi]
LID - S0041-1345(15)00393-0 [pii]
AB  - BACKGROUND: There is an expanding gap between the number of patients listed for
      kidney transplantation and the number of kidney transplantations performed
      annually. The use of sensitive imaging methods results in increased discovery of 
      many urologic asymptomatic problems, such as urolithiases, renal cysts, and solid
      renal masses. This result has brought the question of whether all donors with
      these urologic disorders should be rejected for donation. METHODS: We
      retrospectively analyzed donor and recipient records of all living kidney
      transplantations performed from 2004 to 2014. RESULTS: Among 251 living-related
      donor kidney transplantations, 51 donors (20.3%) had urologic disorders. Mean
      donor age was significantly higher in donors with urologic disorders than in the 
      standard donor group (50 y vs 41 y). The identified disorders were 32 renal
      cysts, 8 urolithiases, 3 renal tumors, 6 adrenal adenomas, and 2 microscopic
      hematurias. After nephrectomy, the graft kidneys with cysts were inspected
      carefully and all of the cortical-peripheral cysts were decorticated. Renal
      tumors were excised in 3 renal units. Transplantations had proceeded after the
      confirmation of low malignancy potentials of the lesions with safe surgical
      margins. Two out of 8 patients had undergone stone removal with ex vivo
      ureteroscopy and 1 by means of pyelotomy incision because of calix neck stenosis.
      None of those donors and recipients developed clinically significant renal stone 
      disease with a mean follow-up of 28 months. Neither donors nor recipients of
      asymptomatic microscopic hematuria patients developed any problem with a mean 28 
      months' follow-up period. CONCLUSIONS: Asymptomatic urologic problems are very
      common. The significance of these asymptomatic pathologies is unclear. Our
      results suggest that in a selected group, at least some of these candidates can
      be accepted for donation.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Tonyali, S
AU  - Tonyali S
AD  - Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Erdem, Y
AU  - Erdem Y
AD  - Division of Nephrology, Department of Internal Medicine, Hacettepe University
      School of Medicine, Ankara, Turkey.
FAU - Yilmaz, S R
AU  - Yilmaz SR
AD  - Division of Nephrology, Department of Internal Medicine, Hacettepe University
      School of Medicine, Ankara, Turkey.
FAU - Erkan, I
AU  - Erkan I
AD  - Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
FAU - Aki, F T
AU  - Aki FT
AD  - Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
      Electronic address: ftuncayaki@yahoo.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Donor Selection/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - *Kidney Transplantation
MH  - Living Donors/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Nephrectomy
MH  - Postoperative Complications/*epidemiology/etiology
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Urologic Diseases/*epidemiology/pathology
EDAT- 2015/06/22 06:00
MHDA- 2016/02/13 06:00
CRDT- 2015/06/22 06:00
PHST- 2015/06/22 06:00 [entrez]
PHST- 2015/06/22 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
AID - S0041-1345(15)00393-0 [pii]
AID - 10.1016/j.transproceed.2015.04.068 [doi]
PST - ppublish
SO  - Transplant Proc. 2015 Jun;47(5):1306-8. doi: 10.1016/j.transproceed.2015.04.068.