PMID- 26086766
OWN - NLM
STAT- MEDLINE
DCOM- 20160427
LR  - 20170220
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 6
DP  - 2015
TI  - Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan
      (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey
      (TOPS).
PG  - e0130716
LID - 10.1371/journal.pone.0130716 [doi]
AB  - BACKGROUND: To develop an OSTAi tool and compare this with the National
      Osteoporosis Foundation recommendations in 2013 (NOF 2013) for bone mineral
      density (BMD) testing among Taiwan postmenopausal women. METHODS: Taiwan
      Osteoporosis Association (TOA) conducted a nationwide BMD survey by a bus
      installed with a dual energy X-ray absorptiometry (DXA) between 2008 and 2011.
      All of the participants completed questionnaire, which included demographics and 
      risk factors of osteoporotic fracture in FRAX tool. We used the database to
      analyze potential risk factors for osteoporosis and followed the model by Koh et 
      al. to develop a risk index via multiple variable regression analysis and item
      reduction. We used the index values to set up a simple algorithm (namely OSTAi)
      to identify those who need BMD measurement. Receiver operating characteristic
      (ROC) curve and the area under the curve (AUC) was used to compare the
      sensitivity/specificity analysis of this model with that of recommendations by
      NOF 2013. RESULTS: A total of 12,175 Taiwan postmenopausal women enrolled in this
      survey. The index value was derived by age and body weight of the participants
      according to weighted odds of each risk factor and the selected cutoff value was 
      set at "-1". There are 6393 (52.5%) participants whose index value is below "-1" 
      and whose risk of osteoporosis was 57.5% (3674/6393). The AUC for OSTAi and NOF
      2013 were 0.739 (95% confidence interval (CI), 0.728-0.749, P<0.001) and 0.618
      (95% CI, 0.606-0.630, P<0.001), respectively. The sensitivity and specificity of 
      OSTAi, at the selected cutoff value of -1, and NOF 2013 to identify osteoporosis 
      were 73.1%, 62.0% and 78.3%, 45.7%, respectively. CONCLUSIONS: As OSTA for Asian 
      populations, OSTAi is an useful tool to identify Taiwan postmenopausal women with
      osteoporosis, In comparison with NOF 2013, OSTAi may be an easier and better tool
      for referral to BMD measurement by DXA in this area.
FAU - Su, Fu-Mei
AU  - Su FM
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
FAU - Liu, Dung-Huan
AU  - Liu DH
AD  - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital,
      Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
FAU - Chen, Jia-Feng
AU  - Chen JF
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
FAU - Yu, Shan-Fu
AU  - Yu SF
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Chiu, Wen-Chan
AU  - Chiu WC
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
FAU - Hsu, Chung-Yuan
AU  - Hsu CY
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
FAU - Ko, Chi-Hua
AU  - Ko CH
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
FAU - Tsai, Ching-Chou
AU  - Tsai CC
AD  - Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of
      Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,
      Taiwan.
FAU - Cheng, Tien-Tsai
AU  - Cheng TT
AD  - Division of Rheumatology, Allergy, and Immunology, Department of Internal
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung
      University College of Medicine, Kaohsiung, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150618
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Absorptiometry, Photon
MH  - Aged
MH  - *Bone Density
MH  - Diagnostic Self Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/*diagnostic imaging/*epidemiology
MH  - ROC Curve
MH  - Risk Factors
MH  - Taiwan/epidemiology
PMC - PMC4473006
EDAT- 2015/06/19 06:00
MHDA- 2016/04/28 06:00
CRDT- 2015/06/19 06:00
PHST- 2015/02/04 00:00 [received]
PHST- 2015/05/23 00:00 [accepted]
PHST- 2015/06/19 06:00 [entrez]
PHST- 2015/06/19 06:00 [pubmed]
PHST- 2016/04/28 06:00 [medline]
AID - 10.1371/journal.pone.0130716 [doi]
AID - PONE-D-15-04783 [pii]
PST - epublish
SO  - PLoS One. 2015 Jun 18;10(6):e0130716. doi: 10.1371/journal.pone.0130716.
      eCollection 2015.